DNA修復|慶應義塾大学 薬学部 分子腫瘍薬学講座
慶應義塾大学薬学部 芝共立キャンパス
〒105-8512 
東京都港区芝公園1-5-30 3号館 8階

論文一覧

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DNA修復経路に関わる代表論文(柴田が責任または筆頭著者)
DNA損傷応答とがん免疫制御に関わる代表論文(柴田が責任著者)

論文

2024
  • Shunji Haruna, Ken Okuda, Akiko Shibata, Mayu Isono, Kohei Tateno, Hiro Sato, Takahiro Oike, Yuki Uchihara, Yu Kato, Atsushi Shibata
    Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation
    Radiother Oncol., in press
  • Nho Cong Luong, Hidemasa Kawamura, Hiroko Ikeda, Reiko T. Roppongi, Atsushi Shibata, Jiaxuan Hu, Jinmeng G. Jiang, David S. Yu & Kathryn D. Held
    ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair
    Int J Radiat Biol., 1-12, 2024
2023
  • Hidekazu Oyoshi#, Junyan Du#, Shunsuke A Sakai, Riu Yamashita, Masayuki Okumura, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Hidenari Hirata, Hironori Sunakawa, Daisuke Kotani, Tomonori Yano, Takashi Kojima, Yuka Nakamura, Motohiro Kojima, Ayako Suzuki, Junko Zenkoh, Katsuya Tsuchihara, Tetsuo Akimoto, Atsushi Shibata*, Yutaka Suzuki* and Shun-Ichiro Kageyama*
    Comprehensive single cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumour in oesophageal squamous cell carcinoma
    Science Advances, 9(50):eadh9069, 2023
  • Yuki Uchihara and Atsushi Shibata*
    Regulation of DNA damage-induced HLA Class I presentation
    DNA Repair, in press
  • Haruka Okami, Naoya Ozawa, Makoto Sohda, Takehiko Yokobori, Katsuya Osone, Bilguun Erkhem-Ochir, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Tatsuya Miyazaki, Hiroomi Ogawa, Takashi Yao, Takahiro Oike, Hiro Sato, Ken Shirabe, Atsushi Shibata, Hiroshi Saeki
    HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis
    IJMS, 24(17):13648, 2023
  • Takahiro Oike, Sangeeta Kakoti, Makoto Sakai, Akihiko Matsumura, Tatsuya Ohno and Atsushi Shibata*
    Analysis of the relationship between LET, γH2AX foci volume and cell killing effect of carbon ions using high-resolution imaging technology
    Journal of Radiation Research, 2023
    2022
    • Kohei Okada, Hiro Sato, Takuya Kumazawa, Yasumasa Mori, Tiara Bunga Mayang Permata, Yuki Uchihara, Shin-ei Noda, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Soehartati Gondhowiardjo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata
      Calreticulin upregulation in cervical cancer tissues from patients following 10 Gy radiotherapy
      Advances in Radiation Oncology, 2022
    • Atsushi Shibata*
      Carbon ion radiation and clustered DNA double-strand breaks
      Enzymes, 51:117-130, 2022
      *Corresponding author
    • Narisa DM Darwis, Eisuke Horigome, Shan Li, Akiko Adachi, Takahiro Oike, Atsushi Shibata, Yuka Hirota, Tatsuya Ohno
      Radiosensitization by the Selective Pan-FGFR Inhibitor LY2874455
      Cells, 11(11):1727, 2022
    • Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, Naoki Hosen, Takaaki Yasuhara, Atsushi Shibata*
      DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
      Molecular Cell, 82(14):2557-2570, 2022
      *Corresponding author
    • Takaaki Yasuhara#*, Reona Kato#, Motohiro Yamauchi, Yuki Uchihara, Lee Zou, Kiyoshi Miyagawa*, Atsushi Shibata*
      RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
      Cell Reports, 38, 110335, 2022
      *Co-corresponding authors, #Co-first
    • Takuya Kumazawa, Yasumasa Mori, Hiro Sato, Tiara Bunga Mayang Permata, Yuki Uchihara, Shin-Ei Noda, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Soehartati Gondhowiardjo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata
      Expression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation
      Oncology Letters, 23(1):29, 2022
    2021
    • Ankita Nachankar, Takahiro Oike, Hirofumi Hanaoka, Ayaka Kanai, Hiro Sato, Yukari Yoshida, Hideru Obinata, Makoto Sakai, Naoto Osu, Yuka Hirota, Akihisa Takahashi, Atsushi Shibata, Tatsuya Ohno.
      64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity.
      Cancers,13(24), 6159,2021.
    • Hirotomo Takatsuka, Atsushi Shibata, Masaaki Umeda.
      Genome Maintenance Mechanisms at the Chromatin Level.
      International Journal of Molecular Sciences, 22(19), 10384,2021.
    • Atsushi Shibata*, Penny A. Jeggo.
      ATM’s Role in the Repair of DNA Double-Strand Breaks.
      Genes, 12(9), 1370, 2021.
      *Corresponding author
    • Palina Kot, Takaaki Yasuhara, Atsushi Shibata, Miyako Hirakawa, Yu Abe, Motohiro Yamauchi, Naoki Matsuda.
      Mechanism of chromosome rearrangement arising from single-strand breaks.
      Biochemical and Biophysical Research Communications, 572:191-196, 2021.
    • Tiara Bunga Mayang Permata, Hiro Sato, Wenchao Gu, Sangeeta Kakoti, Yuki Uchihara, Yukihiko Yoshimatsu, Itaru Sato, Reona Kato, Motohiro Yamauchi, Keiji Suzuki, Takahiro Oike, Yoshito Tsushima, Soehartati Gondhowiardjo, Tatsuya Ohno, Takaaki Yasuhara, Atsushi Shibata*.
      High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.
      Journal of Radiation Research, 62(5):773-781, 2021.
      *Corresponding author
    • Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Atsushi Shibata*.
      Modulation of immune responses by DNA damage signaling.
      DNA Repair, 104:103135, 2021.
      *Corresponding author
    • Yasumasa Mori, Hiro Sato, Takuya Kumazawa, Tiara Bunga Mayang Permata, Yuya Yoshimoto, Kazutoshi Murata, Shin-Ei Noda, Takuya Kaminuma, Ken Ando, Takahiro Oike, Noriyuki Okonogi, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata.
      Analysis of radiotherapy‑induced alteration of CD8+ T cells and PD‑L1 expression in patients with uterine cervical squamous cell carcinoma.
      Oncology Letters, 21(6):446, 2021.
    • Takahiro Oike#, Yuki Uchihara#, Tiara Bunga Mayang Permata, Soehartati Gondhowiardjo, Tatsuya Ohno, Atsushi Shibata*.
      Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy.
      Medical Molecular Morphology, 54(2):166-172, 2021.
      *Corresponding author, #Co-first
    2020
    • Takahiro Oike, Yuka Hirota, Narisa Dewi Maulany Darwis, Atsushi Shibata, Tatsuya Ohno.
      Comparison of Clonogenic Survival Data Obtained by Pre- and Post-Irradiation Methods.
      Journal of Personalized Medicine, 10(4) 171 – 171, 2020.
    • Atsushi Shibata and Penny A Jeggo.
      Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.
      Journal of Radiation Research, 61(5):718-726, 2020
    • Sangeeta Kakoti, Hiro Sato, Siddhartha Laskar, Takaaki Yasuhara and Atsushi Shibata*.
      DNA Repair and Signaling in Immune-Related Cancer Therapy.
      Frontiers in Molecular Biosciences, Sep 8;7:205, 2020
      *Corresponding author
    • Daijiro Kobayashi, Takahiro Oike, Kazutoshi Murata, Daisuke Irie, Yuka Hirota, Hiro Sato, Atsushi Shibata, Tatsuya Ohno.
      Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy.
      Journal of Personalized Medicine, 10(3) 110-110, 2020.
    • Atsushi Shibata, Penny A. Jeggo.
      Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks .
      DNA Repair, 93 102915-102915, 2020.
    • Takahiro Oike , Shuichiro Komatsu , Yuka Komatsu , Ankita Nachankar , Narisa Dewi Maulany Darwis , Atsushi Shibata and Tatsuya Ohno .
      Reporting of methodologies used for clonogenic assays to determine radiosensitivity.
      Journal of Radiation Research, 61(6):828-831, 2020
    • Naoto Osu , Daijiro Kobayashi , Katsuyuki Shirai , Atsushi Musha , Hiro Sato , Yuka Hirota , Atsushi Shibata , Takahiro Oike and Tatsuya Ohno.
      Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status.
      Journal of Personalized Medicine, 10(3), 71,10.3390/jpm10030071, 2020.
    • Yoko Katsuki, Penny A. Jeggo, Yuki Uchihara, Minoru Takata and Atsushi Shibata*.
      DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling.
      Genome Instability & Disease, 155–171, 2020.
      *Corresponding author
    • Nakako Izumi Nakajima*, Motohiro Yamauchi, Sangeeta Kakoti, Liu Cuihua, Reona Kato, Tiara Bunga Mayang Permata, Moito Iijima, Hirohiko Yajima, Takaaki Yasuhara, Shigeru Yamada, Sumitaka Hasegawa and Atsushi Shibata*.
      RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
      DNA Repair, 91-92:102872, 2020.
      *Co-corresponding authors
    • Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada,Atsushi Shibata, Masato T. Kanemaki, Shinichiro Nakada, Shunichi Takeda and Hiroyuki Sasanuma.
      UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA DoubleStrand Breaks.
      iScience, 23(4): 101027, 2020.
    • Atsushi Shibata and Penny A Jeggo.
      Canonical DNA non-homologous end-joining; capacity versus fidelity.
      The British Journal of Radiology, 93(1115):20190966, 2020
    2019
    • Maxim Shevtsov, Gabriele Multhoff, Elena Mikhaylova, Atsushi Shibata, Irina Guzhova and Boris Margulis.
      Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors.
      International Journal of Molecular Sciences, 20(21), 5284, 2019.
    • Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
      p53 deficiency augments nucleolus instability after ionizing irradiation.
      Oncology Reports, 42(6):2293-2302, 2019
      *Corresponding author
    • Hiro Sato, Penny A. Jeggo and Atsushi Shibata*.
      Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine.
      Cancer Science, 110(11):3415-3423,2019
      *Corresponding author
    • Narisa Dewi Maulany Darwis, Ankita Nachankar, Yasushi Sasaki, Toshiaki Matsui, Shin-ei Noda, Kazutoshi Murata, Tomoaki Tamaki, Ken Ando, Noriyuki Okonogi, Shintaro Shiba, Daisuke Irie, Takuya Kaminuma, Takuya Kumazawa, Mai Anakura, Souichi Yamashita, Takashi Hirakawa, Sangeeta Kakoti, Yuka Hirota, Takashi Tokino, Akira Iwase, Tatsuya Ohno, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
      FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy.
      International Journal of Molecular Sciences, 20(18), 4563, 2019.
    • Toshiaki Matsui, Endang Nuryadi, Shuichiro Komatsu, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
      Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity.
      International Journal of Molecular Sciences, 20(17), 4148, 2019.
    • Shuichiro Komatsu, Takahiro Oike, Yuka Komatsu, Yoshiki Kubota, Makoto Sakai, Toshiaki Matsui, Endang Nuryadi, Tiara Bunga Mayang Permata, Hiro Sato, Hidemasa Kawamura, Masahiko Okamoto, Takuya Kaminuma, Kazutoshi Murata, Naoko Okano, Yuka Hirota, Tatsuya Ohno, Jun-ichi Saitoh, Atsushi Shibata and Takashi Nakano .
      Deep learning-assisted literature mining for in vitro radiosensitivity data.
      Radiotherapy & Oncology, 139, 87–93, 2019.
    • Mai Anakura, Ankita Nachankar, Daijiro Kobayashi, Napapat Amornwichet, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
      Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses.
      International Journal of Molecular Sciences, 20(15), 3635, 2019.
    • Atsushi Shibata, Takaaki Yasuhara.
      Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.
      Impact, Volume 2019, Number 3, pp. 50-51(2), 2019.
    • Maxim Shevtsov*, Hiro Sato, Gabriele Multhoff and Atsushi Shibata*.
      Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.
      Frontiers in Oncology, 9(156): eCollection, 2019.
      *Corresponding author
    • Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Hiro Sato, Takaaki Yasuhara, Takahiro Oike, Soehartati Gondhowiardjo, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
      Base excision repair regulates PD-L1 expression in cancer cells.
      Oncogene, 38(23):4452-4466, 2019.
      *Corresponding author
    • Atsushi Shibata and Penny Jeggo
      A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present.
      International Journal of Radiation Biology, 95(7):945-956, 2019.
    • Yoshihiko Hagiwara#, Takahiro Oike#, Atsuko Niimi#, Motohiro Yamauchi, Hiro Sato, Siripan Limsirichaikul, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
      Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation.
      Journal of Radiation Research, 60(1):69-79 , 2019.
      *Corresponding author
    2018
    • Takaaki Yasuhara#*, Reona Kato#, Yoshihiko Hagiwara, Bunsyo Shiotani, Motohiro Yamauchi, Shinichiro Nakada, Atsushi Shibata* and Kiyoshi Miyagawa*.
      Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
      Cell, 175 (2):558-570, 2018. (引用回数 47 2020年現在)
      *Co-corresponding author, #Co-first
    • Atsushi Shibata, Penny Jeggo and Markus Lobrich.
      The pendulum of the Ku-Ku clock.
      DNA repair, 71:164-171, 2018.
    • Endang Nuryadi#, Yasushi Sasaki#, Yoshihiko Hagiwara# et al., Atsushi Shibata, Tatsuya Ohno, Takashi Tokino, Takahiro Oike and Takashi Nakano.
      Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.
      Oncotarget, 9:32642-32652, 2018.
    • Yoshihiko Hagiwara, Hiro Sato, Tiara Bunga Mayang Permata, Atsuko Niimi, Motohiro Yamauchi, Takahiro Oike, Takashi Nakano and Atsushi Shibata*.
      Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.
      Human Immunology, 79(8):627-631, 2018.
      *Corresponding author
    2017
    • Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano and Atsushi Shibata*.
      DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
      Nature Communications, 8(1):1751, 2017. (引用回数  100  2020年現在)
      *Corresponding author
    • Yoshihiko Hagiwara, Atsuko Niimi, Mayu Isono, Motohiro Yamauchi, Takaaki Yasuhara, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
      3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.
      Oncotarget, 8:109370-109381, 2017.
      *Corresponding author
    • Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, Atsushi Shibata, Tsukasa Matsunaga & Kuniyoshi Iwabuchi .
      Aquarius is required for proper CtIP expression and homologous recombination repair.
      Scientific Reports, 7:13808, 2017.
    • Atsushi Shibata*.
      Regulation of repair pathway choice at two-ended DNA double-strand breaks.
      Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 803-805:51-55, 2017.
      *Corresponding author
    • Nakako Izumi Nakajima, Atsuko Niimi, Mayu Isono, Takahiro Oike, Hiro Sato, Takashi Nakano, and Atsushi Shibata*.
      Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.
      Oncology Reports, 38: 693-702, 2017.
      *Corresponding author
    • Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano and Atsushi Shibata*.
      BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation.
      Cell Reports, 18(2):520-532, 2017. (引用回数 62 2020年現在)
      *Corresponding author
    • Ronja Biehs, Monika Steinlage, Olivia Barton, Szilvia Juhasz, Julia Kunzel, Julian Spies, Atsushi Shibata*, Penny Jeggo* and Markus Lobrich*.
      DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.
      Molecular Cell, S1097-2765(16)30854-1, 2017. (引用回数 102 2020年現在)
      *Co-corresponding authors
    • Motohiro Yamauchi, Atsushi Shibata Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda.
      Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1.
      Scientific Reports, 7:41812, 2017.
    • Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno and Takashi Nakano.
      Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon and cisplatin.
      Scientific Reports, 7:40588, 2017.
    2016
    • Atsuko Niimi, Motohiro Yamauchi, Siripan Limsirichaikul, Ryota Sekine, Takahiro Oike, Hiro Sato, Keiji Suzuki, Kathryn D. Held, Takashi Nakano, and Atsushi Shibata*.
      Identification of DNA Double Strand Breaks at Chromosome Boundaries Along the Track of Particle Irradiation.
      Genes, Chromosomes and Cancer, 55(8):650-60, 2016.
      *Corresponding author
    • Takahiro Oike, Atsuko Niimi, Noriyuki Okonogi, Kazutoshi Murata, Akihiko Matsumura, Shin-Ei Noda, Daijiro Kobayashi, Mototaro Iwanaga, Keisuke Tsuchida, Tatsuaki Kanai, Tatsuya Ohno, Atsushi Shibata* & Takashi Nakano*.
      Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.
      Scientific Reports, 6:22275, 2016.
      *Corresponding author
    • Laura A. Tookman, Ashley K. Browne, Claire M. Connell, Gemma Bridge, Carin K. Ingemarsdotter, Suzanne Dowson,Atsushi Shibata, Michelle Lockley, Sarah A. Martin, and Iain A. McNeish.
      RAD51 and BRCA2 promote oncolytic adenovirus type 5 activity in ovarian cancer.
      Molecular Cancer Research, 14(1):44-55, 2016.
    2015
    • Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, Atsushi Shibata Andreas Kakarougkas, and Penny Jeggo.
      SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.
      Nucleic Acids Research, 43(16):7931-44, 2015.
    • Naoyuki Okita and Atsushi Shibata*.
      Other Determinants of Sensitivity (Chapter 15).
      PARP Inhibitors for Cancer Therapy, Cancer Drug Discovery and Development 83, 2015
      *Corresponding author
    • Napapat Amornwichet, Takahiro Oike, Atsushi Shibata, Chaitanya S. Nirodi, Hideaki Ogiwara, Haruhiko Makino, Yuka Kimura, Yuka Hirota, Mayu Isono, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno & Takashi Nakano.
      The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.
      Scientific Reports, srep11305, 2015 Jun 11.
    • Mayu Isono, Yukari Yoshida, Akihisa Takahashi, Takahiro Oike, Atsushi Shibata, Yoshiki Kubota, Tatsuaki Kanai, Tatsuya Ohno, and Takashi Nakano.
      Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.
      Journal of Radiation Research, 56(5):856-61, 2015.
    • Nakako Izumi Nakajima#, Yoshihiko Hagiwara#, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, and Atsushi Shibata*.
      Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
      PLOS ONE, 10(3):e0122582, 2015.
      #Equal first author. *Corresponding author
    2014
    • Atsushi Shibata, Penny Jeggo.
      DNA double-strand break repair in a cellular context.
      Clinical Oncology(R Coll Radiol), 26(5):243-9, 2014.
    • Napapat Amornwichet, Takahiro Oike , Atsushi Shibata, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, Mayu Isono, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno, Takashi Nakano.
      Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe.
      PLOS ONE, 9(12):e115121, 2014.
    • Atsushi Shibata, Davide Moiani, Andrew S. Arvai, Jefferson Perry, Shane M. Harding, Marie-Michelle Genois, Ranjan Maity, Sari van Rossum-Fikkert, Aryandi Kertokalio, Filippo Romoli, Amani Ismail, Ermal Ismalaj, Elena Petricci, Matthew J. Neale, Robert G. Bristow, Jean-Yves Masson, Claire Wyman, Penny A. Jeggo, John A. Tainer.
      DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
      Molecular Cell, 53 (1), 7-18, 2014.(引用回数 325 2020年現在)
    2013
    • Nakako Izumi Nakajima, Holly Brunton, Ritsuko Watanabe, Amruta Shrikhande, Ryoichi Hirayama,  Naruhiro Matsufuji, Akira Fujimori, Takeshi Murakami, Ryuichi Okayasu, Penny Jeggo and Atsushi Shibata*.
      Visualisation of gH2AX foci caused by heavy ion particle traversal; Distinction between core track versus non-track damage.
      PLOS ONE, 14;8(8):e70107, 2013.
      *corresponding author
    • Andreas Kakarougkas, Amani Ismail, Yoko Katsuki, Raimundo Freire, Atsushi Shibata and Penny Jeggo.
      Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.
      Nucleic Acids Research, 41(22):10298-311, 2013.
    • Andreas Kakarougkas, Amani Ismail, Karolin Klement, Aaron Goodarzi, Sandro Conrad, Raimundo Freire, Atsushi Shibata, Markus Löbrich and Penny Jeggo.
      Opposing roles for 53BP1 during homologous recombination.
      Nucleic Acids Research, 41(21), 9719-9731, 2013.
    2012年以前 テニュアトラック就任前
    2011
    • Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, R. Scott Hansen, Penny A. Jeggo* and Atsushi Shibata*.
      Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.
      Molecular and Cellular Biology, 31(19):4022-4035, 2011.
      *corresponding author
    • Lisa Woodbine, Holly Brunton, Aaron A. Goodarzi, Atsushi Shibata, and Penny A. Jeggo*.
      Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
      Nucleic Acids Research, 39(16):6986-6997, 2011.
    • Atsushi Shibata, Sandro Conrad, Julie Birraux, Verena Geuting, Olivia Barton, Amani Ismail, Andreas Kakarougkas, Katheryn Meek, Gisela Taucher-Scholz, Markus Löbrich and Penny A Jeggo*.
      Factors determining DNA double-strand break repair pathway choice in G2 phase.
      EMBO J, 30(6):1079-92, 2011.(引用回数 399 2020現在)
    • Claire M. Connell#, Atsushi Shibata#, Laura A. Tookman, Kyra Archibald, Magdalena B. Flak, Katrina J. Pirlo, Michelle Lockley, Sally P. Wheatley, Iain A. McNeish*.
      Genomic DNA damage and ATR-Chk1 signalling determine oncolytic adenoviral efficacy in human ovarian cancer.
      Journal of Clinical Investigation, 121(4):1283-97, 2011.
      #These authors contributed equally to this work.
    2010
    • Dana A. Löser#, Atsushi Shibata#, Akiko K. Shibata, Lisa J. Woodbine, Penny A. Jeggo and Anthony J. Chalmer*.
      Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.
      Molecular Cancer Therapeutics, 9 (6),1775-87, 2010.
      #These authors contributed equally to this work.(引用回数 120 2020年現在)
    • Atsushi Shibata, Olivia Barton, Angela T. Noon, Kirsten Dahm, Dorothee Deckbar,Aaron A. Goodarzi, Markus Löbrich, and Penny A. Jeggo*.
      Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G2/M checkpoint arrest.
      Molecular and Cellular Biology, 30 (13), 3371–3383, 2010.(引用回数 121 2020年現在)
    • Angela T. Noon, Atsushi Shibata, Nicole Rief, Markus Löbrich, Grant S. Stewart, Penny A. Jeggo* and Aaron A. Goodarzi*.
      53BP1-dependent robust localized KAP‑1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
      Nature Cell Biology, 12 (2), 177-184, 2010.(引用回数 315 2020年現在)
    • Markus Löbrich, Atsushi Shibata, Andrea Beucher, Anna Fisher, Michael Ensminger, Aaron A. Goodarzi, Olivia Barton and Penny A. Jeggo*.
      gH2AX foci analysis for monitoring DNA double-strand break repair – Strengths, limitations and optimization.
      Cell Cycle, 9 (4), 662-669, 2010.(引用回数 566 2020年現在)
    2009
    • Andrea Beucher, Julie Birraux, Leopoldine Tchouandong, Olivia Barton, Atsushi Shibata, Sandro Conrad, Aaron A Goodarzi, Andrea Krempler, Penny A Jeggo*, and Markus Löbrich*.
      ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
      EMBO J, 28, 3413-3427, 2009.(引用回数 445 2020年現在)
    • Atsushi Shibata, Olivia Barton, Angela T. Noon, Dorothee Deckbar, Aaron A. Goodarzi, Markus Löbrich and Penny A. Jeggo*.
      The maintenance of ATM dependent G2/M checkpoint arrest following exposure to ionizing radiation.
      Acta Med. Nagasaki, Vol. 53, 19-21, 2009
    • Atsushi Shibata, Daisuke Maeda, Hideki Ogino, Masahiro Tsustsumi, Takehiko Nohmi, Hitoshi Nakagama, Takashi Sugimura, Hirobumi Teraoka and Mitsuko Masutani*.
      Role of Parp-1 in suppressing spontaneous deletion mutation at non-repeat or short repeat of mononucleotide sequences in the mouse liver in the process of aging.
      Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 664, 20-27, 2009.
    2006
    • Ryo Sakasai, Keitaro Shinohe, Yosuke Ichijima, Naoyuki Okita, Atsushi Shibata, Kinji Asahina and Hirobumi Teraoka.
      Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
      Genes to Cells, Vol. 11, 237-246, 2006.
    • Hideki Ogino, Atsushi Shibata, Akemi Gunji, Hiroshi Suzuki, Hitoshi Nakagama, Takashi Sugimura, Mitsuko Masutani.
      Agent-dependent effects of Parp-1 deficiency on DNA damage responses and genomic stability in mouse ES cells. In: Grier EV (ed), New Developments in Stem Cell Research, Hauppauge, New York, USA.
      Nova Science Publishers, Inc, pp 133-147, 2006.
    2005
    • Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani.
      Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
      Oncogene, 24, 1328-1337, 2005.
    2004
    • Atsushi Shibata, Mitsuko Masutani, Nobuo Kamada, Ken-ichi Masumura, Hitoshi Nakagama, Shizuko Kobayashi, Hirobumi Teraoka, Hiroshi Suzuki and Takehiko Nohmi.
      Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes.
      Environmental and Molecular Mutagenesis, 43, 204-207, 2004.
    2003
    • Atsushi Shibata, Mitsuko Masutani, Tadashige Nozaki, Nobuo Kamada, Hisako Fujihara, Ken-ichi Masumura, Hitoshi Nakagama, Takashi Sugimura, Shizuko Kobayashi, Hiroshi Suzuki and Takehiko Nohmi.
      Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation.
      Environmental and Molecular Mutagenesis, 41, 370-372, 2003.
    2002
    • Mitsuko Masutani, Takushi Shimokawa, Masayuki Igarashi, Masa Hamada, Atsushi Shibata, Sachiho Oami, Tadashige Nozaki, Hitoshi Nakagama, Takashi Sugimura, Tomio Takeuchi, Makoto Hori.
      Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues.
      Proceedings of the Japan Academy, Vol. 78, Ser. B, No. 1, 2002.

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