DNA修復|慶應義塾大学 薬学部 分子腫瘍薬学講座
慶應義塾大学薬学部 芝共立キャンパス
東京都港区芝公園1-5-30 3号館 8階

GDN journal

NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei, NAR, 2022

Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK, Nature Comm., 2022

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance, Nature, 2021

MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”, Mol Cell, 2022

ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations, bioRxiv preprint

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair, Nat Commun. 2021 Sep 17;12(1):5512.

POINT technology illuminates the processing of polymerase-associated intact nascent transcripts, Mol Cell. 2021 May 6;81(9):1935-1950

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair, Cell, Volume 184, Issue 12, 10 June 2021, Pages 3267-3280

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair, Mol Cell 2021, Molecular Cell 81, 1–17

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination, Nature, 596, pages433–437 (2021)

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage, bioRxiv preprint
Replication stress promotes cell elimination by extrusion, Nature. 2021 May;593(7860):591-596.

2021.7.8(香崎さん )
An aged immune system drives senescence and ageing of solid organs, Nature, 2021 Jun;594(7861):100-105.

ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP, PNAS, March 23, 2021 118 (12) e2022600118

2021.6.10(村山 泰斗先生 ゲスト)
DNA Binding by the Mis4Scc2 Loader Promotes Topological DNA Entrapment by the Cohesin Ring, Cell Reports, 33, 108357, November 10, 2020

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1 BioRxiv, 2021 from Daniel Durocher Lab

2021.5.20(中村恭介先生 ゲスト)
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination, Mol Cell. 2021 Mar 4;81(5):1084-1099.

RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination, VOLUME 184, ISSUE 5, P1314-1329, MARCH 04, 2021

The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment. Science Advances 18 Dec 2020, Vol. 6, no. 51, eabb8626

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks Nature Communications, (2020) 11:5775 

2021.1.28(澁谷 大輝先生 ゲスト)

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination Mol Cell, Volume 77, Issue 1, 2 January 2020, Pages 26-38

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy Nature Immunology, 21, pages1160–1171(2020)

2020.11.25(宮成 悠介先生 ゲスト)
Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion
Molecular Cell Volume 78, Issue 3, 7 May 2020, Pages 493-505.e8

METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Molecular Cell 79, 425–442, 2020

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
Science Advances 08 Jan 2020

過去のjournal clubの動画は、Youtubeの限定公開にてラボメンバーに公開しています。