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2023年－－－－
Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration, Cell
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts, Nat Comm
Chromatin compartmentalization regulates the response to DNA damage, Nature [おすすめ]
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei, Mol Cell
DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C, Mol Cell
DICERribonucleaseremovesharmfulR-loops, Mol Cell
AntagonisticrolesofcanonicalandAlternative-RPA indisease-associatedtandemCAGrepeatinstability, Cell
Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis, Nature
MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1, NAR
RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment, NAR
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner, EMBO Rep
ZEB1 promotes non-homologous end joining double-strand break repair, NAR
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining, NAR
Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors, Nat Comm
Short Double-Stranded DNA (≤40-bp) Affects Repair Pathway Choice, IJMS
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity, EMBO J
The complementarity of DDR, nucleic acids and anti-tumour immunity, Nature
The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy, Science Immunology
Break-induced replication orchestrates resection-dependent template switching, Nature
DNA double-strand break end synapsis by DNA loop extrusion, Nat Comm
ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining, NAR
SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology, Mol Cell
Sequence and chromatin features guide DNA double-strand break resection initiation, Mol Cell [おすすめ]
Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer, Nat Comm
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence, NCB [おすすめ]
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres, NSMB [おすすめ]
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops, Cell Rep
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei, Nat Comm
Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response, Molecular Cell
2022年－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations, Molecular Cell
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer, Science Immunology [おすすめ]
Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells, Science Advances
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect, Nature Cancer
Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer, Nature Materials
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response, Nature
Predicting tumour radiosensitivity to deliver precision radiotherapy, Nature Reviews Clinical Oncology
The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops, PNAS
Active DNA demethylation promotes cell fate specification and the DNA damage response, Science
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation, Cell Rep
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes, Nature
CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway, Nat Comm.
Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq, Nat Comm.
Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy, PNAS
CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair, Mol Cell
A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation, Nat Comm.
Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing, Nat Comm.
BRD4 promotes resection and homology-directed repair of DNA double-strand breaks, Nat Comm.
Targeting replication stress in cancer therapy, Nature Reviews Drug Discovery
Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism, Science Signaling
S1-END-seq reveals DNA secondary structures in human cells, Mol Cell
RAD51 protects human cells from transcription-replication conflicts, Mol Cell
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells, Mol Cell
Increasing cell size remodels the proteome and promotes senescence, Mol Cell
Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50, Mol Cell
Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition, JCB
Deciphering the immunopeptidome in vivo reveals new tumour antigens, Nature
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress, Science
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling, NCB
RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity, Nat Comm
Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells, JBC
BRD4 promotes resection and homology-directed repair of DNA double-strand breaks MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation, Science Signaling
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer, Nature Communications
Mre11-Rad50 oligomerization promotes DNA double-strand break repair, Nature Communications
The use of machine learning to discover regulatory networks controlling biological systems, Mol Cell
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress, Science
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ, Mol Cell
Human topoisomerases and their roles in genome stability and organization, Nature Review
NBS1-CtIP–mediated DNA end resection suppresses cGAS binding to micronuclei, NAR [おすすめ]
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1, Mol Cell
Telomere dysfunction in ageing and age-related diseases, Nat Cell Biol, review
The threat of programmed DNA damage to neuronal genome integrity and plasticity, Nature Genetics
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1, PNAS
BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer, Clin. Transl. Med.
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières syndrome–like encephalopathy, Immunity
ResOU https://resou.osaka-u.ac.jp/ja
53BP1 regulates heterochromatin through liquid phase separation, Nat Comm
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis, Nature [おすすめ]
cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status, bioRxiv
Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling, Oncogene
DNA-PK inhibitor peposertib amplifies radiation-induced inflammatory micronucleation and enhances TGFβ/PD-L1 targeted cancer immunotherapy, Mol Can Res
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway Science Signaling
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion, Cell
Assessing kinetics and recruitment of DNA repair factors using high content screens, Cell Reports
2021年－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial, Nat Cancer
Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study, The Lancet Oncology
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing, Mol Cell
Radiation Therapy Enhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial, Nat Cancer
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion, Cell
ER-directed TREX1 limits cGAS activation at micronuclei, Mol Cell
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51, Nature
RPA phosphorylation facilitates RAD52 dependent homologous recombination in BRCA-deficient cells, MCB
IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer, Cell Reports
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair, Neuron
DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutie`res syndrome after RNASEH2 disruption, Neuron (review)
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation, Nature
The effect of hypoxia on PD-L1 expression in bladder cancer, BMC Cancer
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage, Sci Adv
The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage, PNAS
DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks, JCS
Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair, Mol Cell
~2020年－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation, Clin Cancer Res
DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement, Mol Cell, 2020
Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates, NSMB, 2017