DNA修復 | 群馬大学 柴田研究室



Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism, Science Signaling

S1-END-seq reveals DNA secondary structures in human cells, Mol Cell

RAD51 protects human cells from transcription-replication conflicts, Mol Cell

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells, Mol Cell

Increasing cell size remodels the proteome and promotes senescence, Mol Cell

Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50, Mol Cell

Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition, JCB

Deciphering the immunopeptidome in vivo reveals new tumour antigens, Nature

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress, Science

Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling, NCB

RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity, Nat Comm

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells, JBC

BRD4 promotes resection and homology-directed repair of DNA double-strand breaks MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation, Science Signaling

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer, Nature Communications

Mre11-Rad50 oligomerization promotes DNA double-strand break repair, Nature Communications

The use of machine learning to discover regulatory networks controlling biological systems, Mol Cell

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress, Science

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ, Mol Cell

Human topoisomerases and their roles in genome stability and organization, Nature Review

NBS1-CtIP–mediated DNA end resection suppresses cGAS binding to micronuclei, NAR

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1, Mol Cell

Telomere dysfunction in ageing and age-related diseases, Nat Cell Biol, review

The threat of programmed DNA damage to neuronal genome integrity and plasticity, Nature Genetics

Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1, PNAS

BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer, Clin. Transl. Med.

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières syndrome–like encephalopathy, Immunity

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53BP1 regulates heterochromatin through liquid phase separation, Nat Comm

53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis, Nature

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status, bioRxiv

Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling, Oncogene

DNA-PK inhibitor peposertib amplifies radiation-induced inflammatory micronucleation and enhances TGFβ/PD-L1 targeted cancer immunotherapy, Mol Can Res

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway Science Signaling

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion, Cell

Assessing kinetics and recruitment of DNA repair factors using high content screens, Cell Reports

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial, Nat Cancer

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing, Mol Cell

Radiation Therapy Enhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial, Nat Cancer

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion, Cell

ER-directed TREX1 limits cGAS activation at micronuclei, Mol Cell

HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51, Nature

RPA phosphorylation facilitates RAD52 dependent homologous recombination in BRCA-deficient cells, MCB

IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer, Cell Reports

Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair, Neuron
DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutie`res syndrome after RNASEH2 disruption, Neuron (review)

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation, Nature

The effect of hypoxia on PD-L1 expression in bladder cancer, BMC Cancer

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage, Sci Adv

The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage, PNAS

DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks, JCS

Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair, Mol Cell

Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation, Clin Cancer Res

DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement, Mol Cell, 2020

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates, NSMB, 2017