DNA修復 | 群馬大学 柴田研究室



53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis, Nature

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status, bioRxiv

Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling, Oncogene

DNA-PK inhibitor peposertib amplifies radiation-induced inflammatory micronucleation and enhances TGFβ/PD-L1 targeted cancer immunotherapy, Mol Can Res

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway Science Signaling

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion, Cell

Assessing kinetics and recruitment of DNA repair factors using high content screens, Cell Reports

HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51, Nature

RPA phosphorylation facilitates RAD52 dependent homologous recombination in BRCA-deficient cells, MCB

IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer, Cell Reports

Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair, Neuron
DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutie`res syndrome after RNASEH2 disruption, Neuron (review)

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation, Nature

The effect of hypoxia on PD-L1 expression in bladder cancer, BMC Cancer

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage, Sci Adv

The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage, PNAS

DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks, JCS