2022年－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières syndrome–like encephalopathy, Immunity
ResOU https://resou.osaka-u.ac.jp/ja
53BP1 regulates heterochromatin through liquid phase separation, Nat Comm
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis, Nature
cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status, bioRxiv
Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling, Oncogene
DNA-PK inhibitor peposertib amplifies radiation-induced inflammatory micronucleation and enhances TGFβ/PD-L1 targeted cancer immunotherapy, Mol Can Res
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway Science Signaling
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion, Cell
Assessing kinetics and recruitment of DNA repair factors using high content screens, Cell Reports
2021年－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51, Nature
RPA phosphorylation facilitates RAD52 dependent homologous recombination in BRCA-deficient cells, MCB
IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer, Cell Reports
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair, Neuron
DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutie`res syndrome after RNASEH2 disruption, Neuron (review)
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation, Nature
The effect of hypoxia on PD-L1 expression in bladder cancer, BMC Cancer
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage, Sci Adv
The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage, PNAS
DUSP6 regulates radio-sensitivity in glioblastoma by modulating the recruitment of p-DNAPKcs at DNA double-strand breaks, JCS