SHIBATA LAB

Division of Molecular Oncological Pharmacy
Keio University Faculty of Pharmacy

University administrative affairs, ordering, budget management

University administrative affairs, ordering, budget management

“Verification of DNA repair ability under chronic inflammation”

Tokyo Metropolitan University
2013: Obtained degree

1. Isono et al., Cell Reports, 2017.

2. Nakazawa et al., Cell, 2020.

3. Hagiwara et al., Oncotarget, 2017.

4. Sato et al., Nat Comm, 2017.
5. Nakajima et al., Oncol Rep, 2017.
6. Kobayashi et al., Sci Rep, 2017.
7. Amornwichet et al., Sci Rep, 2015.

Lab manager, ordering, budget management, experiment assistance

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Researchmap

Graduated from Keio University Faculty of Science and Technology
Graduated from Tsukuba University Faculty of Medicine

“Elucidation of immune control mechanisms after DNA damage with the aim of developing new treatments for malignant gliomas”
Social significance:Brain tumors are known to have an extremely low survival rate, and the treatment for brain tumors remains the same as the one proposed by Stupp et al. in 2006. If we could develop a new brain tumor treatment method through research into DNA damage that occurs during chemoradiotherapy, which is essential for the treatment of brain tumors, it would make a great contribution to the cure of cancer.

Cell culture, immunofluorescence staining, flow cytometry, bioinformatics

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41st Tsukuba Neurosurgery Society Excellent Paper Award, Case Report Category
40th Tsukuba Neurosurgery Society Excellent Presentation Award, Basic Research Category
Best Poster Presentation, Faculty of Medicine, University of Tsukuba, FY2014

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Graduated from Keio University Faculty of Pharmacy

“Identification of cells responsible for anti-tumor immunity in the cancer microenvironment after chemoradiotherapy and development of novel treatments”
Social significance:It is becoming clear that immune levels change after chemotherapy and radiation therapy, but it is still unknown which immune cells should be targeted for treatment. Therefore, by identifying the responsible cells and target molecules, we hope to develop a method to manipulate them and lead to the development of new cancer treatments originating from the Keio University Faculty of Pharmacy.

Cell culture, Western blot, flow cytometry, bioinformatics

1. Haruna et al.Radiother Oncol, 2024. First author
2. Oike&Okuda et al. Adv Radiat Oncol, in press. Co-author

★2024 Indonesia International Cancer Conference, Best Abstract Award
★2024 1st Integrated Radiation Science Retreat, Best Presentation Award
★2023 The 143rd Annual Meeting of the Pharmaceutical Society of Japan, Student Outstanding Presentation Award

I am grateful for the environment that allows me to conduct research, and will continue to work hard every day to contribute to society.

Graduated from Keio University Faculty of Pharmacy

“Analysis of cancer immune responses after DNA damage using tumor organoids”
Social significance:Cancer cells in the human body naturally grow three-dimensionally. Conventional two-dimensional culture methods using dishes were unable to reproduce the three-dimensional properties specific to cancer, but by using organoids, also known as mini-organs, we will elucidate the original cancer immune response that occurs after DNA damage, which will lead to the development of truly effective new cancer treatments.

Cell culture, organoid culture, flow cytometry, bioinformatics

1. Oike&Okuda et al. Adv Radiat Oncol, in press. First author
2. Haruna et al.Radiother Oncol, 2024. Co-author

★2024 Indonesia International Cancer Conference, Best Abstract Award
★2024 1st Integrated Radiation Science Retreat, Best Discussor Award
★2023 The 143rd Annual Meeting of the Pharmaceutical Society of Japan, Student Outstanding Presentation Award

I will do my best to conduct research that will serve as the foundation for immunotherapy for intractable cancers.

Extraction of DNA damage repair features in esophageal cancer and optimization of tumor immunity

Cell culture, immunofluorescence staining, flow cytometry, bioinformatics

1. Haruna et al.Radiother Oncol, 2024. Co-author
2. Oike&Okuda et al. Adv Radiat Oncol, in press. Co-author

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I will continue to absorb as much as I can and work hard every day so that I can apply the results of my research to the clinical setting.

Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

“Understanding the chromatin structure that regulates DSB repair pathways”
Social significance:DNA in the cell nucleus is stored in a wide variety of chromatin structures. On the other hand, it is known that when DNA damage occurs, the chromatin structure in the nucleus changes dynamically. However, it is still unclear how such chromatin dynamic changes occur. Therefore, we would like to clarify the relationship between DNA repair and chromatin structure from two aspects: 1) the chromatin state before DNA damage occurs, and 2) the chromatin structure change after DNA damage, using ultra-high resolution imaging analysis and next-generation sequencing analysis, and to be the first in the world to clarify the basic principle of how chromatin structure affects DNA repair. We are working hard every day to connect the knowledge gained from basic research to the development of new cancer treatments.

Hayashi et al., JRR, 2024 Co-author

★2024 67th Annual Meeting of the Japanese Radiation Society Excellent Presentation Award

I would like to devote myself to my research every day, aiming to make new discoveries that will lead to treatment.

Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

“Developing new cancer treatment methods by elucidating the mechanism of epithelial-mesenchymal transition in cancer cells”
Social significance:Epithelial-mesenchymal transition in cancer cells is an obstacle to cancer treatment, as it can lead to the acquisition of anticancer drug resistance and enhanced invasiveness. On the other hand, it is known that induction of epithelial-mesenchymal transition in cancer cells can make them highly sensitive to certain metabolic inhibitors. Therefore, we aim to elucidate the molecular mechanisms that cause this hypersensitivity to metabolic inhibitors and propose new therapies that focus on epithelial-mesenchymal transition.
[I am currently working at the Cancer Research Institute (Ariake) Cancer Chemotherapy Center, Genome Research Department]

I would be happy if I could contribute even a little to cancer research, and I would like to do my best in this favorable environment.

Graduated from Gunma University Faculty of Science and Technology

“Research into DNA damage response induced by changes in intracellular metabolic environment”
Social significance:In DNA repair research to date, very few studies have focused on intracellular metabolic pathways. Therefore, we will clarify the effect of fluctuations in ATP, the intracellular energy currency, on DNA repair pathways. Meanwhile, by elucidating how the amount of ATP changes when DNA damage occurs, we will clarify how DNA repair and ATP are linked, and pioneer a new field of DNA repair and metabolism.

★2024 4th Young Radiation Effects Research Association Young Researcher Outstanding Presentation Award
★2024 61st Annual Meeting of the Biological Division of the Japanese Society for Radiation Oncology, Outstanding Presentation Award
★2023 66th Annual Meeting of the Japan Radiation Research Society, Outstanding Presentation Award

Hayashi et al., JRR, 2024 Fist author

We will work to elucidate the whole picture of DNA repair.

Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

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Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

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Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

I am building a complete bioinformatics environment in the Shibata lab: building analysis formats from raw data using RNA-seq, scRNA-seq, ATAC-seq, and ChIP-seq. In addition, I am creating user-friendly apps and training videos. These will be applied to both cancer research and DNA repair in the Shibata lab, but my master’s thesis is mainly about immune gene expression regulation mechanisms in cancer research.

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