DNA Repair | SHIBATA LAB/DNA Repair Laboratory, JAPAN
Keio University Shiba Kyoritsu Campus
8th Floor, Building 3, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512

Professor

Atsushi Shibata

My lifework

Understanding DNA repair reactions

Research projects
  1. DNA double-strand break repair research
  2. Signal transduction research during cancer treatment
Research record

Google Scholar Profile
Researchmap
Full citation 8221
h index 42
i10 Index 86

My hometown

Ibaraki Prefecture

My word

Continuing self-control

My favorite

Maki Ohguro, Mr. Children

Back ground

March 2001 Kyoritsu College of Pharmacy, Faculty of medicine Department, Japan Bachelor of Pharmacy (Keio University School of Pharmacy)
March 2003 Kyoritsu College of Pharmacy, Japan Degree of Pharmaceutical Master
April 2004 Tokyo Medical and Dental University, Japan Japan Society for the Promotion of Science, Fellowship DC1
March 2006 Tokyo Medical and Dental University, Japan Medical and Dental Sciences Postdoctoral Degree (Ph.D, medicine)
April 2006 University of Sussex, UK Visiting JSPS postdoctoral fellow (PD) in Prof. Penny A. Jeggo lab
April 2007 University of Sussex, UK Postdoctoral fellow in Prof. Penny A. Jeggo lab
October 2012 University of Sussex, UK Senior research fellow in Prof. Penny A. Jeggo lab (supported by JSPS postdoctoral fellowship for Research Abroad)
March 2013 Gunma University, Japan Tenure-track Program Advanced Scientific Research Leaders Development (ASRLD) Unit, Assistant professor (Principal Investigator)
April 2017 Gunma University, Japan Education and Research Support Center (ERSC) Senior Lecturer (Principal Investigator)
April 2018~ Kyoto University, Japan Radiation Biology Center (RBC) Visiting Associate Professor
April 2019~
Gunma University, Japan Gunma University Initiative for Advanced Research (GIAR)
Associate Professor (Principal Investigator) https://www.giar.gunma-u.ac.jp/
October 2019~
Gunma University, Japan
Gunma University Initiative for Advanced Research Viral Vector Core Associate Professor /Concurrent post https://synapse.dept.med.gunma-u.ac.jp/vvcenter/

Message

Under Construction

Position

Keio University Faculty of Pharmacy Professor
Radiation Biology Center, Kyoto University Visiting Professor

degree

Doctor of Medicine (March 17, 2006)

driver licence

Pharmacist license (June 21, 2001)

Awards
2020 Radiation Effects Research Encouragement Award (Radiation Effects Association)
2017 Radiation Research Society Encouragement Award
2017 The 60th Annual Meeting of the Japan Radiation Research Society, Excellent Presentation Award
2017 24th Workshop on DNA Replication, Recombination and Repair Young Researcher Presentation Award
2012 Poster prize (3 out of ~50 posters); Joint British Association for Cancer Research-Gray Institute in Oxford
2010 Highly rated poster presentations (top 2-3%); the AACR 101st Annual Meeting
Affiliated Academic Societies

Radiation Effects Society, Radiation Biology Research, JASTRO Biological Division, Japanese Cancer Association, Molecular Biology Society of Japan, Japanese Biochemical Society, Pharmaceutical Society of Japan, Japanese Society of Anti-Aging Medicine, Japanese Society of Phosphatase Research

post

Academic Council Member, Japan Radiation Research Society
Japanese Society for Radiation Oncology, Biological Society Secretary
DNA Repair (Editorial Board)
NAR Cancer (Editorial Board)
Frontiers in Aging (Editorial Board (past))

Educational Background

Assistant Professor

Shunji Haruna

My lifework

Coming soon

Research projects

Coming soon

Research record

Coming soon

My hometown

Coming soon

My word

Coming soon

My favorite

Coming soon

Position

Coming soon

degree

Coming soon

driver licence

Coming soon

Awards

Coming soon

Affiliated Academic Societies

Coming soon

post

Coming soon

Educational Background

Coming soon

Secretary

Saika Yamagata

Job Description

University administrative affairs, Laboratory Assistant

Kumagai Tamae

Job Description

University administrative affairs, ordering, budget management

Miki Takanashi

Job Description

University administrative affairs, ordering, budget management

Lab Staff

Mayu Isono 【Lab Manager】

Research Project

“Verification of DNA repair ability under chronic inflammation”

Education

Tokyo Metropolitan University
2013: Obtained degree

Publications
  1. Isono et al., Cell Reports, 2017.
  2. Nakazawa et al., Cell, 2020.

  3. Hagiwara et al., Oncotarget, 2017.

  4. Sato et al., Nat Comm, 2017.
  5. Nakajima et al., Oncol Rep, 2017.
  6. Kobayashi et al., Sci Rep, 2017.
  7. Amornwichet et al., Sci Rep, 2015.
Job Description

Lab manager, ordering, budget management, experiment assistance

Research record

Google Scholar
Researchmap

Graduate student

Hikaru Okumura (PhD student, JST-SPRING)

Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

Project:

“Understanding the chromatin structure that regulates DSB repair pathways”
Social significance:
DNA in the cell nucleus is stored in a wide variety of chromatin structures. On the other hand, it is known that when DNA damage occurs, the chromatin structure in the nucleus changes dynamically. However, it is still unclear how such chromatin dynamic changes occur. Therefore, we would like to clarify the relationship between DNA repair and chromatin structure from two aspects: 1) the chromatin state before DNA damage occurs, and 2) the chromatin structure change after DNA damage, using ultra-high resolution imaging analysis and next-generation sequencing analysis, and to be the first in the world to clarify the basic principle of how chromatin structure affects DNA repair. We are working hard every day to connect the knowledge gained from basic research to the development of new cancer treatments.

Publication in SHIBATA lab:

Okumura et al., DNA Repair, 2025 First author
Hayashi et al., JRR, 2024 Co-author

Previous awards:

★2024 67th Annual Meeting of the Japanese Radiation Society Excellent Presentation Award

comment

I would like to devote myself to my research every day, aiming to make new discoveries that will lead to treatment.

Risako Ono (PhD student) *Gunma University

Project:

Coming soon

Skills:

Coming soon

Previous awards:

Coming soon

comment:

Coming soon

Takafumi Nakai (PhD student)

★Cancer Institute (Ariake) Cellular Senescence Department, Akiko Takahashi Laboratory Website ishere.

Project:

Coming soon

Skills:

Coming soon

Previous awards:

Coming soon

comment:

Coming soon

Mayu Oyake (PhD student)

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

Coming soon

Ryota Hayashi (PhD student, JST-SPRING)

Graduated from Gunma University Faculty of Science and Technology

Project:

“Research into DNA damage response induced by changes in intracellular metabolic environment”
Social significance:
In DNA repair research to date, very few studies have focused on intracellular metabolic pathways. Therefore, we will clarify the effect of fluctuations in ATP, the intracellular energy currency, on DNA repair pathways. Meanwhile, by elucidating how the amount of ATP changes when DNA damage occurs, we will clarify how DNA repair and ATP are linked, and pioneer a new field of DNA repair and metabolism.

Previous awards:

★2024 4th Young Radiation Effects Research Association Young Researcher Outstanding Presentation Award
★2024 61st Annual Meeting of the Biological Division of the Japanese Society for Radiation Oncology, Outstanding Presentation Award
★2023 66th Annual Meeting of the Japan Radiation Research Society, Outstanding Presentation Award

Publication in SHIBATA lab:

Hayashi et al., JRR, 2024 Fist author

comment:

We will work to elucidate the whole picture of DNA repair.

Daiki Unami (PhD student)

Graduated from Keio University Faculty of Pharmacy, Department of Pharmaceutical Sciences

Project:

Coming soon

comment:

Coming soon

Haruto Imai (Master student)

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

Coming soon

Haruka Saito (Master student)

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

Coming soon

Taketo Suda (Master student)

★National Institutes for Quantum and Radiological Science and Technology (QST) Quantum Carcinogenesis Team, under the direction of Dr. Tatsuhiko Imaoka(Website ishere.

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

Coming soon

Shu Hashimoto (Master student)

★National Institutes for Quantum and Radiological Science and Technology (QST) Quantum Carcinogenesis Team, under the direction of Dr. Tatsuhiko Imaoka(Website ishere.

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

Coming soon

Kota Muraki (Master student)

Project:

Coming soon

Skills:

Cell culture

Previous awards:

Coming soon

comment:

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Takumi Takahashi (Master student)

Project:

Coming soon

Skills:

Coming soon

Previous awards:

Coming soon

comment:

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Tamaki Saito (Master student)

Project:

Coming soon

Skills:

Coming soon

Previous awards:

Coming soon

comment:

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Yuto Kohara (Master student)

Project:

Coming soon

Skills:

Coming soon

Previous awards:

Coming soon

comment:

Coming soon

Undergraduate student

  • Pharmacy Department (6 years)
  • Marin Isoda

    (6th year student)

  • Kanta Seki

    (6th year student)

  • Yutaro Toichi

    (6th year student)

  • Jundai Hirata

    (6th year student)

  • Yuko Murakami

    (6th year student)

  • Yuta Hara

    (5th year student)

  • Yuki Tanaka

    (5th year student)

  • Ayano Kanagawa

    (5th year student)

  • Riku Okumoto

    (5th year student)

  • Kyogo Nishikawa

    (5th year student)

  • Pharmaceutical Sciences (4-year program)
  • Hiiro Bando

    (4th year student)

  • Kenta Miyamoto

    (4th year student)

  • Koko Ito

    (4th year student)

  • Mika Arakawa

    (4th year student)

Collaborators

External Collaborative Researchers (including past collaborative research)

  • Motohiro Yamauchi

    (Kyushu University, Radioisotope Safety Management Center)

  • Keizi Suzuki

    (Nagasaki University Atomic Bomb Disease Institute)

  • Kensuke Otsuka

    (Central Research Institute of the Electric Power Industry)

  • Yusuke Miyanari

    (Kanazawa University, Nano Life Science Institute)

  • Akiko Katada

    (Kyushu University, Graduate School of Medical Sciences, Department of Applied Stem Cell Science)

  • Masamichi Yamamoto

    (National Cerebral and Cardiovascular Center)

  • Kiyoshi Miyagawa

    (Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo)

  • Takaaki Yasuhara

    (Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo)

  • Takakazu Nakabayashi

    (Tohoku University, Faculty of Pharmaceutical Sciences)

  • Masaaki Umeda

    (Nara Institute of Science and Technology)

  • Tomomi Horiuchi

    (Basic Biology Research Institute)

  • Nakako Nakajima

    (QST)

  • Mayang Permata

    (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia)

  • Soehartati Gondhowiardjo

    (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia)

  • Penny A. Jeggo

    (University of Sussex, UK)

  • Hiroshi Saiki

    (Gunma University, Department of General Surgery, Gastrointestinal Surgery)

  • Takehiko Yokobori

    (Gunma University, Future Research Institute, Yokobori Laboratory)

  • Takahiro Oike

    (Gunma University, Department of Radiation Oncology)

  • Hirohisa Sato

    (Department of Radiological Oncology, Gunma University)

  • Reika Kawabata

    (Gunma University, Future Research Institute, Kawabata Laboratory)


Collaborative Researcher

  • Yoshimasa Sato

    (Keio University, Faculty of Pharmacy, Department of Pharmacology)

Past members

  • Yuya Suzuki

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)

  • Tomoko Ueno

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)  ★Central Research Institute of the Electric Power Industry

  • Kaito Usami

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)

  • Nodoka Taguchi

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)

  • Misaki Hatakeyama

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)

  • Saki Masuda

    (Faculty of Pharmacy, Department of Pharmacy, 2025 Graduate)

  • Ryuta Suzuki

    (Master of Science in Pharmacy, 2025 Graduate)

  • Kunihiro Miyazaki

    (Master of Science in Pharmacy, 2025 Graduate)

  • Ken Okuda

    (PhD in Pharmacy, 2025 Graduate)

    Publication in SHIBATA lab:
    1. Tateno et al. Adv Radiat Oncol, 2026. Co-author
    2. Okuda et al. Med Mol Morphol, 2026. First author
    3. Oike&Okuda et al. Adv Radiat Oncol, 2024. First author
    4. Haruna et al. Radiother Oncol, 2024. Co-author
  • Kohei Tateno

    : Visiting Research Student *Gunma University (April 2023~March 2026)

    Publication in SHIBATA lab:
    1. Tateno et al. Adv Radiat Oncol, 2026. First author
    2. Okuda et al. Med Mol Morphol, 2026. Co-author
    3. Oike&Okuda et al. Adv Radiat Oncol, 2024. Co-author
    4. Haruna et al. Radiother Oncol, 2024. Co-author

  • Takaaki Ishikawa

    : Research Fellow (April 2023~July 2025)

    Publication in SHIBATA lab:

    Tateno et al. Adv Radiat Oncol, 2026. Co-author

  • Kanae Kaneko

    (Faculty of Pharmacy, Department of Pharmacy, 2024 Graduate) ★Cancer Institute (Ariake) Cancer Genome Dynamics Project, External Research Center under Professor Yasukazu Ogaku. Website is here.

  • Ayami Shinozaki

    (Faculty of Pharmacy, Department of Pharmacy, 2024 Graduate)

  • Ayana Osako

    (Faculty of Pharmacy, Department of Pharmacy, 2024 Graduate)

  • Hina Mukaida

    (Faculty of Pharmacy, Department of Pharmacy, 2024 Graduate)

  • Yuki Yaguchi

    (Faculty of Pharmacy, Department of Pharmacy, 2024 Graduate) ★Central Research Institute of the Electric Power Industry

  • Takumi Tazawa

    (Master of Science in Pharmacy, 2024 Graduate)

  • Masaki Kawakami

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Haruka Kamiyama

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Yukiko Nimi

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Moeno Araya

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Iri Nakao

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Miki Habiro

    (Faculty of Pharmacy, Department of Pharmacy, 2023 Graduate)

  • Hiroko Iino

    : Secretary (Until September 2025)

  • Yuki Uchihara

    : Assistant Professor(April 2023~May 2025

  • Yu Kato

    : Assistant Professor(April 2023~March 2024)

  • Akiko Shibata

    Technical Assistant, Gunma University (Until March 2023, Shibata Lab)

  • Lusi Tania Rahmartani

    : Researcher at Gunma University (Until April 2023, Shibata Lab)

  • Naho Takashima

    : Secretary, Gunma University (Until March 2023, Shibata Lab)

  • Yasuyo Sekiguchi

    : Technical Assistant, Gunma University (Until March 2023, Shibata Lab)

  • Yoko Hayashi

    : Technical Assistant, Gunma University (Until March 2023, Shibata Lab)

  • Rintaro Saitou

    Gunma University School of Medicine student (Until March 2023, Shibata Lab)

  • Hiroo Saito

    : Assistant Professor, Gunma University Heavy Ion Medical Promotion Organization(Until June 2021, Shibata Lab) Engaged in research at Shibata Lab as an on-campus collaborative research project

    Publications in SHIBATA Lab
    1. Uchihara et al., Mol Cell, 2022, Co-author
    2. Kumazawa et al., Oncology Letters, 2022 *Corresponding author
    3. Permata#, Sato#, Gu#, Kakoti# et al., JRR, 2021, Co-first author
    4. Uchihara et al., DNA Repair, 2021
    5. Mori et al., Oncology Letters, 2021 *Corresponding author
    6. Kakoti et al., Frontiers in Molecular Biosciences, 2020, Co-author
    7. Kakoti et al., Oncology Reports, 2019 Co-author
    8. Sato et al., Cancer Science, 2019 First author
    9. Shevtsov et al., Frontiers in Oncology, 2019 Co-author
    10. Permata et al., Oncogene, 2019 Co-author
    11. Hagiwara et al., JRR, 2019 Co-author
    12. Hagiwara et al., Human Immunology, 2018 Co-author
    13. Sato et al., Nature Communications, 2017 First author This paper won the Umegai Award from the Japanese Society for Radiation Oncology.
    14. Nakajima et al., Oncology Reports, 2017 Co-author
    15. Isono et al., Cell Reports, 2017 Co-author
    16. Niimi et al., GCC, 2016 Co-author
  • Wenchao Gu

    Gunma University Graduate Student (Until 2020, Shibata Lab)

    Publications in SHIBATA Lab
    1. Permata#, Sato#, Gu#, Kakoti# et al., JRR, 2021, Co-first author
    2. Kakoti
  • Yukihiko Yoshimatsu

    Gunma University School of Medicine student (Until March 2020, Shibata Lab)

  • Itaru Sato

    Gunma University School of Medicine student (Until March 2020, Shibata Lab)

  • Shiho Nakanishi

    Secretary (Until March 2019, Shibata Lab)

  • Yoshimi Omi

    : Technical Assistant (Until September 2019, Shibata Lab)

  • Sangeeta Kakoti

    Gunma University Graduate Student (PhD) (Until March 2020, Shibata Lab)

    Publications in SHIBATA Lab
    1. Mori Y et al., Oncology Letters, 2021, Co-author
    2. Kakoti S et al., Fronteirs in Molecular Biosciences, 2020, First author
    3. Nakajima et al., DNA Repair, 2020. Co-author
    4. Kakoti S et al., Oncology Reports, 2019, First author
    5. Darwis NDM et al., International Journal of Molecular Sciences, 2019 Co-author
    6. Sato H, et al., Nature Communications, 2017, Co-author
  • Mayang Permata

    Gunma University Graduate Student (PhD) (Until October 2018, Shibata Lab)

    Publications in SHIBATA Lab
    1. Oike et al., Medical Molecular Morphology, 2021. Co-author
    2. Nakajima et al., DNA Repair, 2020. Co-author
    3. Komatsu et al., Rad & Oncol., 2019. Co-author
    4. Permata M et al., Oncogene, 2019. First author
    5. Hagiwara Y et al., Human Immunology, 2018. Co-author
    6. Sato H, et al., Nature Communications, 2017. Co-author
  • Mayu Isono

    : Postdoctoral Researcher (Until January 2017, Shibata Lab)

    Publications in SHIBATA Lab
    1. Isono M et al., Cell Reports, 2017. First author
    2. Sato H et al., Nature Communications, 2017. Co-author
    3. Nakajima NI et al., Oncology Reports, 2017. Co-author
    4. Kobayashi D et al., Scientific Reports, 2017. Co-author
    5. Amornwichet N et al., Scientific Reports, 2015. Co-author
  • Ryota Sekine

    Gunma University School of Medicine student (Shibata Lab until 2015)

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