{"id":683,"date":"2021-02-05T09:47:25","date_gmt":"2021-02-05T00:47:25","guid":{"rendered":"https:\/\/shibataxlab.com\/english\/?page_id=683"},"modified":"2025-07-26T12:01:31","modified_gmt":"2025-07-26T03:01:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/shibataxlab.com\/english\/?page_id=683","title":{"rendered":"Publications"},"content":{"rendered":"<section>\n<h5>DSB repair pathway choice<\/h5>\n<ul>\n<li>Transcription associated DSB repair in G1 <span style=\"color: #000000;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35108530\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\"><span style=\"text-decoration: underline;\">Yasuhara et al., <strong>Cell Rep<\/strong>, 2022<\/span><\/a><\/span><\/li>\n<li>HR initiation at transcription active loci <span style=\"color: #000000;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30245011\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Yasuhara et al., <strong>Cell<\/strong>, 2018<\/a><\/span><\/li>\n<li>DSB repair pathway choice in G1 <span style=\"color: #000000;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28132842\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Biehs et al., <strong>Mol Cell<\/strong>, 2017<\/a><\/span><\/li>\n<li>53BP1 dephosphorylation promotes pro-HR environment <span style=\"color: #000000;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28076794\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Isono et al., <strong>Cell Rep<\/strong>, 2017<\/a><\/span><\/li>\n<li>MRE11-dependent initiation of resection <span style=\"color: #000000;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24316220\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Shibata et al., <strong>Mol Cell<\/strong>, 2014<\/a><\/span><\/li>\n<li>DSB repair pathway choice in G2 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21317870\/\" target=\"_blank\" rel=\"noopener\">Shibata et al., <strong>EMBO J<\/strong>, 2011<\/a><\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>DDR dependent immune ligands regulation<\/h5>\n<ul>\n<li>Proof of immunosuppressive macrophages occurring in the tumor microenvironment following radiotherapy <a href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciadv.adh9069?rfr_dat=cr_pub++0pubmed&amp;url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\"><u>Oyoshi et al, <strong>Sci Adv<\/strong>, 2023<\/u><\/a><\/li>\n<li>DNA damage promotes HLA class I presentation <span style=\"text-decoration: underline;\">Uchihara et al., <strong>Mol Cell<\/strong>, 2022<\/span><\/li>\n<li>BER deficiency upregulates PD-L1 expression <span style=\"color: #000000;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30755733\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Permata et al., <strong>Oncogene<\/strong>, 2019<\/a><\/span><\/li>\n<li>DSB-dependent ATR\/Chk1 upregulates PD-L1 expression <span style=\"color: #000000;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21317870\" target=\"_blank\" rel=\"noopener\" style=\"color: #000000;\">Sato et al., <strong>Nat Comm<\/strong>, 2017<\/a><\/span><\/li>\n<\/ul>\n<p><span class=\"bold\">Google Scholar Profile (<a href=\"https:\/\/scholar.google.co.jp\/citations?user=cM4dRzEAAAAJ&amp;hl=ja\" target=\"_blank\" rel=\"noopener\" class=\"blue\">Atsushi Shibata<\/a>)<\/span><\/p>\n<\/section>\n<section>\n<h4 id=\"dissertation-list\">Publication<\/h4>\n<section>\n<h5>2025<\/h5>\n<ul class=\"treatise\">\n<li>Takahiro Oike, Ryosuke Kambe, Narisa Dewi Maulany Darwis, <strong><span style=\"text-decoration: underline;\">Atsushi Shibata<\/span><\/strong>, Tatsuya Ohno<br \/>\nEstablishment of cancer cell radiosensitivity database linked to multi-layer omics data<br \/>\n<em><strong>Cancer Science<\/strong><\/em>, 116(3):690-697, 2025<\/li>\n<li><span style=\"text-decoration: underline;\">Hikaru Okumura<\/span>, <span style=\"text-decoration: underline;\">Ryota Hayashi<\/span>, <span style=\"text-decoration: underline;\">Daiki Unami<\/span>, <span style=\"text-decoration: underline;\">Mayu Isono<\/span>, Motohiro Yamauchi, Kensuke Otsuka, <span style=\"text-decoration: underline;\">Yu Kato<\/span>, Takahiro Oike, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, and <strong><span style=\"text-decoration: underline;\">Atsushi Shibata*<\/span><\/strong><br \/>\nMeCP2 deficiency leads to the \u03b3H2AX nano foci expansion after ionizing radiation<br \/>\n<em><strong>DNA Repair<\/strong><\/em>, 145:103790, 2025<\/li>\n<\/ul>\n<h5>2024<\/h5>\n<ul class=\"treatise\">\n<li>Kensuke Otsuka, Kouki Uchinomiya,<span>\u00a0<\/span><span>Yuki Yaguchi<\/span>,<span>\u00a0<\/span><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span><br \/>\nPrediction of key biological processes from intercellular DNA damage differences through model-based fitting<br \/>\n<em><strong>iScience<\/strong><\/em>, 27(12):111473, 2024<\/li>\n<li>Kie Ozaki, Reona Kato, Takaaki Yasuhara, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, Miyako Hirakawa, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, Kiyoshi Miyagawa, Keiji Suzuki, Naoki Matsuda, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Motohiro Yamauchi*<br \/>\n<em><strong>Scientific Reports<\/strong><\/em>, <span>14(1):18455, 2024<\/span><\/li>\n<li>Takahiro Oike#, <span style=\"text-decoration: underline;\">Ken Okuda#<\/span>, <span style=\"text-decoration: underline;\">Shunji Harun<\/span>a, <span style=\"text-decoration: underline;\">Akiko Shibata<\/span>, <span style=\"text-decoration: underline;\">Ryota Hayashi<\/span>, <span style=\"text-decoration: underline;\">Mayu Isono<\/span>, <span style=\"text-decoration: underline;\">Kohei Tateno<\/span>, Nobuteru Kubo, Akihiko Uchiyama, Sei-Ichiro Motegi, Tatsuya Ohno, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, <span style=\"text-decoration: underline;\">Yu Kato*,<\/span> <strong><span style=\"text-decoration: underline;\">Atsushi Shibata*<\/span><\/strong><br \/>\nExacerbated inflammatory gene expression following impaired G2\/M-checkpoint arrest in fibroblasts derived from a patient exhibiting severe adverse effects<br \/>\n<em><strong>Advances in Radiation Oncology<\/strong><\/em>, <span>9(8):101530, 2024<\/span><\/li>\n<li><span style=\"text-decoration: underline;\">Ryota Hayashi<\/span>, <span style=\"text-decoration: underline;\">Hikaru Okumura<\/span>, <span style=\"text-decoration: underline;\">Mayu Isono<\/span>, Motohiro Yamauchi, <span style=\"text-decoration: underline;\">Daiki Unami<\/span>, Rahmartani Tania Lusi, Masamichi Yamamoto, <span style=\"text-decoration: underline;\">Yu Kato<\/span>, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, <strong><span style=\"text-decoration: underline;\">Atsushi Shibata*<\/span><\/strong><br \/>\nInhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation<br \/>\n<em><strong>J Radiat Res.<\/strong><\/em>, <span>65(3):263-271, 2024<\/span><\/li>\n<li><span style=\"text-decoration: underline;\">Shunji Haruna<\/span>, <span style=\"text-decoration: underline;\">Ken Okuda<\/span>, <span style=\"text-decoration: underline;\">Akiko Shibata<\/span>, <span style=\"text-decoration: underline;\">Mayu Isono<\/span>, <span style=\"text-decoration: underline;\">Kohei Tateno<\/span>, Hiro Sato, Takahiro Oike, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, <span style=\"text-decoration: underline;\">Yu Kato*<\/span>,<strong> <\/strong><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span><br \/>\nCharacterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation<br \/>\n<em><strong>Radiother Oncol.<\/strong><\/em>, <span>194:110198, 2024<\/span><\/li>\n<li>Nho Cong Luong, Hidemasa Kawamura, Hiroko Ikeda, Reiko T. Roppongi, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span><span style=\"letter-spacing: 0.3px;\">, Jiaxuan Hu, Jinmeng G. Jiang, David S. Yu &amp; Kathryn D. Held<\/span><br style=\"letter-spacing: 0.3px;\" \/><span style=\"letter-spacing: 0.3px;\">ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair<\/span><br style=\"letter-spacing: 0.3px;\" \/><em style=\"letter-spacing: 0.3px;\"><strong>Int J Radiat Biol.<\/strong><\/em><span style=\"letter-spacing: 0.3px;\">, 1-12, 2024<\/span><\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2023<\/h5>\n<ul class=\"treatise\">\n<li><span style=\"color: #000000;\">Hidekazu Oyoshi#, Junyan Du#, Shunsuke A Sakai, Riu Yamashita, Masayuki Okumura, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Hidenari Hirata, Hironori Sunakawa, Daisuke Kotani, Tomonori Yano, Takashi Kojima, Yuka Nakamura, Motohiro Kojima, Ayako Suzuki, Junko Zenkoh, Katsuya Tsuchihara, Tetsuo Akimoto, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span>, Yutaka Suzuki* and Shun-Ichiro Kageyama*<\/span><br \/>\n<span style=\"color: #000000;\">Comprehensive single cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumour in oesophageal squamous cell carcinoma<\/span><br \/>\n<strong><em>Science Advances<\/em><\/strong>, 9(50):eadh9069, 2023<\/li>\n<li><span style=\"text-decoration: underline;\">Yuki Uchihara<\/span> and <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<br \/>\n<\/strong><\/span>Regulation of DNA damage-induced HLA Class I presentation<br \/>\n<em><strong>DNA Repair<\/strong><\/em>, <span>132:103590, 2023<\/span><\/li>\n<li>Haruka Okami, Naoya Ozawa, Makoto Sohda, Takehiko Yokobori, Katsuya Osone, Bilguun Erkhem-Ochir, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Tatsuya Miyazaki, Hiroomi Ogawa, Takashi Yao, Takahiro Oike, Hiro Sato, Ken Shirabe, <strong><span style=\"text-decoration: underline;\">Atsushi Shibata<\/span><\/strong>, Hiroshi Saeki<br \/>\nHLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis<br \/>\n<em><strong>IJMS<\/strong><\/em>, 24(17):13648, 2023<\/li>\n<li>Takahiro Oike, <span style=\"text-decoration: underline;\">Sangeeta Kakoti<\/span>, Makoto Sakai, Akihiko Matsumura, Tatsuya Ohno and <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span><br \/>\nAnalysis of the relationship between LET, \u03b3H2AX foci volume and cell killing effect of carbon ions using high-resolution imaging technology<br \/>\n<strong><em>Journal of Radiation Research<\/em><\/strong>, <span>64(2):335-344, 2023<\/span><\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2022<\/h5>\n<ul class=\"treatise\">\n<li>Kohei Okada, Hiro Sato, Takuya Kumazawa, Yasumasa Mori, <span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, Shin-ei Noda, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Soehartati Gondhowiardjo, Takashi Nakano, Tatsuya Ohno, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span><br \/>\nCalreticulin upregulation in cervical cancer tissues from patients following 10 Gy radiotherapy<br \/>\n<em><strong>Advances in Radiation Oncology<\/strong><\/em>, <span>8(3):101159, 2022<\/span><\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<br \/>\n<\/strong><\/span>Carbon ion radiation and clustered DNA double-strand breaks<br \/>\n<em><strong>Enzymes<\/strong><\/em>, 51:117-130, 2022<br \/>\n*Corresponding author<\/li>\n<li>Narisa DM Darwis, Eisuke Horigome, Shan Li, Akiko Adachi, Takahiro Oike, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Yuka Hirota, Tatsuya Ohno<br \/>\nRadiosensitization by the Selective Pan-FGFR Inhibitor LY2874455<br \/>\n<em><strong>Cells<\/strong><\/em>, 11(11):1727, 2022<\/li>\n<li><span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>,<span> <\/span><span>Tiara Bunga Mayang Permata<\/span>, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada,<span> <\/span><span>Wenchao Gu<\/span>,<span> <\/span><span>Sangeeta Kakoti<\/span>, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, Naoki Hosen, Takaaki Yasuhara,<span style=\"text-decoration: underline;\"> <\/span><span><strong><span style=\"text-decoration: underline;\">Atsushi Shibata*<\/span><br \/>\n<\/strong><\/span>DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production<br \/>\n<em><strong>Molecular Cell<\/strong><\/em>, 2022<br \/>\n*Corresponding author<\/li>\n<li>Takaaki Yasuhara*, Reona Kato, Motohiro Yamauchi, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, Lee Zou, Kiyoshi Miyagawa*, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<br \/>\n<\/strong><\/span>RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair<br \/>\n<em><strong>Cell Reports<\/strong><\/em>, 38, 110335, 2022<br \/>\n*Co-corresponding author<\/li>\n<li>Takuya Kumazawa, Yasumasa Mori, Hiro Sato,<span style=\"text-decoration: underline;\"> Tiara Bunga Mayang Permata<\/span>, <span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, Shin-Ei Noda, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Soehartati Gondhowiardjo, Takashi Nakano, Tatsuya Ohno, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span><br \/>\nExpression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation<br \/>\n<em><strong>Oncology Letters<\/strong><\/em>, 23(1):29, 2022<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2021<\/h5>\n<ul class=\"treatise\">\n<li>Ankita Nachankar, Takahiro Oike, Hirofumi Hanaoka, Ayaka Kanai, Hiro Sato, Yukari Yoshida, Hideru Obinata, Makoto Sakai, Naoto Osu, Yuka Hirota, Akihisa Takahashi, <strong><span style=\"text-decoration: underline;\">Atsushi Shibata<\/span><\/strong>, Tatsuya Ohno.<br \/>\nCu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity.<br \/>\n<strong><em>Cancers<\/em><\/strong>,13(24), 6159,2021.<\/li>\n<li>Hirotomo Takatsuka,<span> <\/span><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Masaaki Umeda.<br \/>\nGenome Maintenance Mechanisms at the Chromatin Level.<br \/>\n<strong><em>International Journal of Molecular Sciences<\/em><\/strong>, 22(19), 10384,2021.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<span>*<\/span><\/strong><\/span>, Penny A. Jeggo.<br \/>\nATM\u2019s Role in the Repair of DNA Double-Strand Breaks.<br \/>\n<em><strong>Genes,<span> <\/span><\/strong><\/em>12(9), 1370, 2021.<br \/>\n<span>*Corresponding author<\/span><\/li>\n<li>Palina Kot, Takaaki Yasuhara,<span> <\/span><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Miyako Hirakawa, Yu Abe, Motohiro Yamauchi, Naoki Matsuda.<br \/>\nMechanism of chromosome rearrangement arising from single-strand breaks.<br \/>\n<em><strong>Biochemical and Biophysical Research Communications<\/strong><\/em>, 572:191-196, 2021.<\/li>\n<li><span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, Hiro Sato, <span style=\"text-decoration: underline;\">Wenchao Gu<\/span>, Sangeeta Kakoti,<span> <\/span><span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, Yukihiko Yoshimatsu,<span style=\"text-decoration: underline;\"> Itaru Sato<\/span>, Reona Kato, Motohiro Yamauchi, Keiji Suzuki, Takahiro Oike, Yoshito Tsushima, Soehartati Gondhowiardjo, Tatsuya Ohno, Takaaki Yasuhara,<span> <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span><\/span>.<br \/>\nHigh linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.<br \/>\n<strong><em>Journal of Radiation Research<\/em><\/strong>, <span>62(5):773-781<\/span>,<span> <\/span><span>2021.<br \/>\n*Corresponding author<br \/>\n<\/span><\/li>\n<li><span style=\"text-decoration: underline;\">Yuki Uchihara<\/span>, <span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, Hiro Sato, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span>.<span style=\"text-decoration: underline;\"><strong><br \/>\n<\/strong><\/span>Modulation of immune responses by DNA damage signaling.<br \/>\n<em><strong>DNA Repair<\/strong><\/em>, 104:103135, 2021.<br \/>\n<span>*Corresponding author<\/span><\/li>\n<li>Yasumasa Mori, Hiro Sato, Takuya Kumazawa,<span style=\"text-decoration: underline;\"> Tiara Bunga Mayang Permata<\/span>, Yuya Yoshimoto, Kazutoshi Murata, Shin-Ei Noda, Takuya Kaminuma, Ken Ando, Takahiro Oike, Noriyuki Okonogi, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Takashi Nakano, Tatsuya Ohno, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>.<br \/>\nAnalysis of radiotherapy\u2011induced alteration of CD8+ T cells and PD\u2011L1 expression in patients with uterine cervical squamous cell carcinoma.<br \/>\n<em><strong>Oncology Letters<\/strong><\/em><span>, Jun;21(6):446, 2021.<\/span><\/li>\n<li>Takahiro Oike#,<span style=\"text-decoration: underline;\"> Yuki Uchihara#<\/span>,<span> <\/span><span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, Soehartati Gondhowiardjo, Tatsuya Ohno,<span> <\/span><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*<\/strong><\/span>.<br \/>\nQuantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy.<br \/>\n<em><strong>Medical Molecular Morphology<\/strong><\/em>, 54(2):166-172, 2021.<br \/>\n*Corresponding author, #Co-first<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2020<\/h5>\n<ul class=\"treatise\">\n<li>Takahiro Oike, Yuka Hirota, Narisa Dewi Maulany Darwis, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Tatsuya Ohno.<br \/>\nComparison of Clonogenic Survival Data Obtained by Pre- and Post-Irradiation Methods.<br \/>\n<em><strong>Journal of Personalized Medicine,<\/strong><\/em> 10(4) 171 \u2013 171, 2020.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span> and Penny A Jeggo.<br \/>\nRoles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.<br \/>\n<em><strong>Journal of Radiation Research,<\/strong><\/em> <span>61(5):718-726, 2020<\/span><\/li>\n<li><span style=\"text-decoration: underline;\">Sangeeta Kakoti,<\/span> Hiro Sato, Siddhartha Laskar, Takaaki Yasuhara and <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*.<\/strong><\/span><br \/>\nDNA Repair and Signaling in Immune-Related Cancer Therapy.<br \/>\n<em><strong>Frontiers in Molecular Biosciences,<\/strong><\/em> Sep 8;7:205, 2020<br \/>\n*Corresponding author<\/li>\n<li>Daijiro Kobayashi, Takahiro Oike, Kazutoshi Murata, Daisuke Irie, Yuka Hirota, Hiro Sato, <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Tatsuya Ohno.<br \/>\nInduction of Micronuclei in Cervical Cancer Treated with Radiotherapy.<br \/>\n<em><strong>Journal of Personalized Medicine,<\/strong><\/em> 10(3) 110-110, 2020.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Penny A. Jeggo.<br \/>\nRoles for 53BP1 in the repair of radiation-induced DNA double strand breaks .<br \/>\n<em><strong>DNA Repair,<\/strong><\/em> 93 102915-102915, 2020.<\/li>\n<li>Takahiro Oike , Shuichiro Komatsu , Yuka Komatsu , Ankita Nachankar , Narisa Dewi Maulany Darwis , <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span> and Tatsuya Ohno .<br \/>\nReporting of methodologies used for clonogenic assays to determine radiosensitivity.<br \/>\n<em><strong>Journal of Radiation Research,<\/strong><\/em> 61(6):828-831, 2020<\/li>\n<li>Naoto Osu , Daijiro Kobayashi , Katsuyuki Shirai , Atsushi Musha , Hiro Sato , Yuka Hirota , <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span> , Takahiro Oike and Tatsuya Ohno.<br \/>\nRelative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status.<br \/>\n<em><strong>Journal of Personalized Medicine,<\/strong><\/em> 10(3), 71,10.3390\/jpm10030071, 2020.<\/li>\n<li>Yoko Katsuki, Penny A. Jeggo, Yuki Uchihara, Minoru Takata and <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*.<\/strong><\/span><br \/>\nDNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling.<br \/>\n<em><strong>Genome Instability &amp; Disease,<\/strong><\/em> 155\u2013171, 2020.<br \/>\n*Corresponding author<\/li>\n<li>Nakako Izumi Nakajima*, Motohiro Yamauchi, <span style=\"text-decoration: underline;\">Sangeeta Kakoti<\/span>, Liu Cuihua, Reona Kato, <span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, Moito Iijima, Hirohiko Yajima, Takaaki Yasuhara, Shigeru Yamada, Sumitaka Hasegawa and <span style=\"text-decoration: underline;\"><strong>Atsushi Shibata*.<\/strong><\/span><br \/>\nRNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.<br \/>\n<em><strong>DNA Repair,<\/strong><\/em> 91-92:102872, 2020.<br \/>\n*Co-corresponding author<\/li>\n<li>Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada,<span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span>, Masato T. Kanemaki, Shinichiro Nakada, Shunichi Takeda and Hiroyuki Sasanuma.<br \/>\nUBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA DoubleStrand Breaks.<br \/>\n<em><strong>iScience<\/strong><\/em>, 23(4): 101027, 2020.<\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Atsushi Shibata<\/strong><\/span> and Penny A Jeggo.<br \/>\nCanonical DNA non-homologous end-joining; capacity versus fidelity.<br \/>\n<em><strong>The British Journal of Radiology,<\/strong><\/em> 93(1115):20190966, 2020<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2019<\/h5>\n<ul class=\"treatise\">\n<li>Maxim Shevtsov, Gabriele Multhoff, Elena Mikhaylova, <span class=\"bold uline\">Atsushi Shibata<\/span>, Irina Guzhova and Boris Margulis.<br \/>\nCombination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors.<br \/>\n<span class=\"bold italic\">International Journal of Molecular Sciences,<\/span> 20(21), 5284, 2019.<\/li>\n<li><span class=\"uline\">Sangeeta Kakoti<\/span>, Motohiro Yamauchi, <span class=\"uline\">Wenchao Gu<\/span>, Reona Kato, Takaaki Yasuhara, <span class=\"uline\">Yoshihiko Hagiwara<\/span>, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\np53 deficiency augments nucleolus instability after ionizing irradiation.<br \/>\n<span class=\"bold italic\">Oncology Reports,<\/span> 42(6):2293-2302, 2019<br \/>\n*Corresponding author<\/li>\n<li>Hiro Sato, Penny A. Jeggo and <span class=\"bold uline\">Atsushi Shibata*<\/span>.<br \/>\nRegulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine.<br \/>\n<span class=\"bold italic\">Cancer Science,<\/span> 110(11):3415-3423,2019<br \/>\n*Corresponding author<\/li>\n<li>Narisa Dewi Maulany Darwis, Ankita Nachankar, Yasushi Sasaki, Toshiaki Matsui, Shin-ei Noda, Kazutoshi Murata, Tomoaki Tamaki, Ken Ando, Noriyuki Okonogi, Shintaro Shiba, Daisuke Irie, Takuya Kaminuma, Takuya Kumazawa, Mai Anakura, Souichi Yamashita, Takashi Hirakawa, <span class=\"uline\">Sangeeta Kakoti,<\/span> Yuka Hirota, Takashi Tokino, Akira Iwase, Tatsuya Ohno, <span class=\"uline bold\">Atsushi Shibata<\/span>, Takahiro Oike and Takashi Nakano.<br \/>\nFGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy.<br \/>\n<span class=\"bold italic\">International Journal of Molecular Sciences,<\/span> 20(18), 4563, 2019.<\/li>\n<li>Toshiaki Matsui, Endang Nuryadi, Shuichiro Komatsu, Yuka Hirota, <span class=\"bold uline\">Atsushi Shibata,<\/span> Takahiro Oike and Takashi Nakano.<br \/>\nRobustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity.<br \/>\n<span class=\"bold italic\">International Journal of Molecular Sciences,<\/span> 20(17), 4148, 2019.<\/li>\n<li>Shuichiro Komatsu, Takahiro Oike, Yuka Komatsu, Yoshiki Kubota, Makoto Sakai, Toshiaki Matsui, Endang Nuryadi, <span style=\"text-decoration: underline;\">Tiara Bunga Mayang Permata<\/span>, Hiro Sato, Hidemasa Kawamura, Masahiko Okamoto, Takuya Kaminuma, Kazutoshi Murata, Naoko Okano, Yuka Hirota, Tatsuya Ohno, Jun-ichi Saitoh, <span class=\"bold uline\">Atsushi Shibata<\/span> and Takashi Nakano .<br \/>\nDeep learning-assisted literature mining for in vitro radiosensitivity data.<br \/>\n<span class=\"bold italic\">Radiotherapy &amp; Oncology,<\/span> 139, 87\u201393, 2019.<\/li>\n<li>Mai Anakura, Ankita Nachankar, Daijiro Kobayashi, Napapat Amornwichet, Yuka Hirota, <span class=\"bold uline\">Atsushi Shibata,<\/span> Takahiro Oike and Takashi Nakano.<br \/>\nRadiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses.<br \/>\n<span class=\"bold italic\">International Journal of Molecular Sciences,<\/span> 20(15), 3635, 2019.<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata,<\/span> Takaaki Yasuhara.<br \/>\nElucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.<br \/>\n<span class=\"bold italic\">Impact,<\/span> Volume 2019, Number 3, pp. 50-51(2), 2019.<\/li>\n<li>Maxim Shevtsov*, Hiro Sato, Gabriele Multhoff and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nNovel Approaches to Improve the Efficacy of Immuno-Radiotherapy.<br \/>\n<span class=\"bold italic\">Frontiers in Oncology,<\/span> 9(156): eCollection, 2019.<br \/>\n*Corresponding author<\/li>\n<li>Tiara Bunga Mayang Permata, <span class=\"uline\">Yoshihiko Hagiwara<\/span>, Hiro Sato, Takaaki Yasuhara, Takahiro Oike, Soehartati Gondhowiardjo, Kathryn D. Held, Takashi Nakano &amp; <span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\nBase excision repair regulates PD-L1 expression in cancer cells.<br \/>\n<span class=\"bold italic\">Oncogene,<\/span> 10.1038\/s41388-019-0733-6, 2019.<br \/>\n*Corresponding author<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span> and Penny Jeggo*<br \/>\nA historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present.<br \/>\n<span class=\"bold italic\">International Journal of Radiation Biology ,<\/span> 10.1080\/09553002, 2019.<br \/>\n*Corresponding author<\/li>\n<li><span class=\"uline\">Yoshihiko Hagiwara<\/span>#, Takahiro Oike#, Atsuko Niimi#, Motohiro Yamauchi, Hiro Sato, Siripan Limsirichaikul, Kathryn D. Held, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nClustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation.<br \/>\n<span class=\"bold italic\">Journal of Radiation Research,<\/span> 60(1):69-79 , 2019.<br \/>\n*Corresponding author<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2018<\/h5>\n<ul class=\"treatise\">\n<li>Takaaki Yasuhara#*, Reona Kato#, <span class=\"uline\">Yoshihiko Hagiwara<\/span>, Bunsyo Shiotani, Motohiro Yamauchi, Shinichiro Nakada, <span class=\"bold uline\">Atsushi Shibata<\/span>* and Kiyoshi Miyagawa*.<br \/>\nHuman Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.<br \/>\n<span class=\"bold italic\">Cell,<\/span> 175 (2):558-570, 2018. \uff08citation 47: 2020\uff09<br \/>\n*Co-corresponding author<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Penny Jeggo and Markus Lobrich.<br \/>\nThe pendulum of the Ku-Ku clock.<br \/>\n<span class=\"bold italic\">DNA repair,<\/span> 71:164-171, 2018.<\/li>\n<li>Endang Nuryadi#, Yasushi Sasaki#, <span class=\"uline\">Yoshihiko Hagiwara#<\/span> et al., <span class=\"bold uline\">Atsushi Shibata<\/span>, Tatsuya Ohno, Takashi Tokino, Takahiro<br \/>\nOike and Takashi Nakano.<br \/>\nMutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.<br \/>\n<span class=\"bold italic\">Oncotarget,<\/span> 9:32642-32652, 2018.<\/li>\n<li><span class=\"uline\">Yoshihiko Hagiwara<\/span>, Hiro Sato, Tiara Bunga Mayang Permata, Atsuko Niimi, Motohiro Yamauchi, Takahiro Oike, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nAnalysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.<br \/>\n<span class=\"bold italic\">Human Immunology,<\/span> 79(8):627-631, 2018.<br \/>\n*Corresponding author<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2017<\/h5>\n<ul class=\"treatise\">\n<li>Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, <span class=\"uline\"><\/span>Yoshihiko Hagiwara, <span class=\"uline\">Mayu Isono<\/span>, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata*<\/span>.<br \/>\nDNA double-strand break repair pathway regulates PD-L1 expression in cancer cells<br \/>\n<span class=\"bold italic\">Nature Communications,<\/span> 8(1):1751, 2017. \uff08citation 100: 2020\uff09<br \/>\n*Corresponding author<\/li>\n<li><span class=\"uline\">Yoshihiko Hagiwara<\/span>, Atsuko Niimi, <span class=\"uline\">Mayu Isono<\/span>, Motohiro Yamauchi, Takaaki Yasuhara, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\n3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread \u03b3H2AX foci after high LET heavy-ion particle radiation.<br \/>\n<span class=\"bold italic\">Oncotarget,<\/span> 8:109370-109381, 2017.<br \/>\n*Corresponding author<\/li>\n<li>Ryo Sakasai,<span class=\"uline\"> Mayu Isono<\/span>, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, <span class=\"bold uline\">Atsushi Shibata<\/span>, Tsukasa Matsunaga &amp; Kuniyoshi Iwabuchi .<br \/>\nAquarius is required for proper CtIP expression and homologous recombination repair.<br \/>\n<span class=\"bold italic\">Scientific Reports,<\/span> 7:13808, 2017.<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\nRegulation of repair pathway choice at two-ended DNA double-strand breaks.<br \/>\n<span class=\"bold italic\">Mutation Research\/Fundamental and Molecular Mechanisms of Mutagenesis,<\/span> 803-805:51-55, 2017.<br \/>\n*Corresponding author<\/li>\n<li>Nakako Izumi Nakajima, Atsuko Niimi, Mayu Isono, Takahiro Oike, Hiro Sato, Takashi Nakano, and <span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\nInhibition of the HDAC\/Suv39\/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.<br \/>\n<span class=\"bold italic\">Oncology Reports,<\/span> 38: 693-702, 2017.<br \/>\n*Corresponding author<\/li>\n<li><span class=\"uline\">Mayu Isono<\/span>, Atsuko Niimi, Takahiro Oike, <span class=\"uline\">Yoshihiko Hagiwara<\/span>, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano and <span class=\"bold uline\">Atsushi Shibata*.<\/span><br \/>\nBRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation.<br \/>\n<span class=\"bold italic\">Cell Reports,<\/span> 18(2):520-532, 2017. \uff08citation 62: 2020\uff09<br \/>\n*Corresponding author<\/li>\n<li>Ronja Biehs, Monika Steinlage, Olivia Barton, Szilvia Juhasz, Julia Kunzel, Julian Spies, <span class=\"bold uline\">Atsushi Shibata*<\/span>, Penny Jeggo* and Markus Lobrich*.<br \/>\nDNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.<br \/>\n<span class=\"bold italic\">Molecular Cell,<\/span>S1097-2765(16)30854-1, 2017. \uff08citation 102: 2020\uff09<br \/>\n*Co-corresponding authors<\/li>\n<li>Motohiro Yamauchi, <span class=\"bold uline\">Atsushi Shibata<\/span>, Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda.<br \/>\nRegulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1.<br \/>\n<span class=\"bold italic\">Scientific Reports,<\/span> 7:41812, 2017.<\/li>\n<li>Daijiro Kobayashi, Takahiro Oike, <span class=\"bold uline\">Atsushi Shibata<\/span>, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, <span class=\"uline\">Yoshihiko Hagiwara<\/span>, Yuka Kimura, Yuka Hirota, Hiro Sato, <span class=\"uline\">Mayu Isono<\/span>, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno and Takashi Nakano.<br \/>\nMitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon and cisplatin.<br \/>\n<span class=\"bold italic\">Scientific Reports,<\/span> 7:40588, 2017.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2016<\/h5>\n<ul class=\"treatise\">\n<li>Atsuko Niimi, Motohiro Yamauchi, Siripan Limsirichaikul, Ryota Sekine, Takahiro Oike, Hiro Sato, Keiji Suzuki, Kathryn D. Held, Takashi Nakano, and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nIdentification of DNA Double Strand Breaks at Chromosome Boundaries Along the Track of Particle Irradiation.<br \/>\n<span class=\"bold italic\">Genes, Chromosomes and Cancer,<\/span>55(8):650-60, 2016.<br \/>\n*Corresponding author<\/li>\n<li>Takahiro Oike, Atsuko Niimi, Noriyuki Okonogi, Kazutoshi Murata, Akihiko Matsumura, Shin-Ei Noda, Daijiro Kobayashi, Mototaro Iwanaga, Keisuke Tsuchida, Tatsuaki Kanai, Tatsuya Ohno, <span class=\"bold uline\">Atsushi Shibata<\/span>* &amp; Takashi Nakano*.<br \/>\nVisualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.<br \/>\n<span class=\"bold italic\">Scientific Reports,<\/span> 6:22275, 2016.<br \/>\n*Corresponding author<\/li>\n<li>Laura A. Tookman, Ashley K. Browne, Claire M. Connell, Gemma Bridge, Carin K. Ingemarsdotter, Suzanne Dowson, <span class=\"bold uline\">Atsushi Shibata<\/span>, Michelle Lockley, Sarah A. Martin, and Iain A. McNeish.<br \/>\nRAD51 and BRCA2 promote oncolytic adenovirus type 5 activity in ovarian cancer.<br \/>\n<span class=\"bold italic\">Molecular Cancer Research,<\/span> 14(1):44-55, 2016.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2015<\/h5>\n<ul class=\"treatise\">\n<li>Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, <span class=\"bold uline\">Atsushi Shibata<\/span>, Andreas Kakarougkas, and Penny Jeggo.<br \/>\nSETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.<br \/>\n<span class=\"bold italic\">Nucleic Acids Research,<\/span> 43(16):7931-44, 2015.<\/li>\n<li>Naoyuki Okita and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nOther Determinants of Sensitivity (Chapter 15).<br \/>\nPARP Inhibitors for Cancer Therapy, Cancer Drug Discovery and Development 83, 2015<br \/>\n*Corresponding author<\/li>\n<li>Napapat Amornwichet, Takahiro Oike, <span class=\"bold uline\">Atsushi Shibata<\/span>, Chaitanya S. Nirodi, Hideaki Ogiwara, Haruhiko Makino, Yuka Kimura, Yuka Hirota, <span class=\"uline\">Mayu Isono<\/span>, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno &amp; Takashi Nakano.<br \/>\nThe EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.<br \/>\n<span class=\"bold italic\">Scientific Reports,<\/span> srep11305, 2015 Jun 11.<\/li>\n<li><span class=\"uline\">Mayu Isono<\/span>, Yukari Yoshida, <span class=\"bold uline\">Akihisa Takahashi<\/span>, Takahiro Oike, Atsushi Shibata, Yoshiki Kubota, Tatsuaki Kanai, Tatsuya Ohno, and Takashi Nakano.<br \/>\nCarbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.<br \/>\n<span class=\"bold italic\">Journal of Radiation Research,<\/span> 56(5):856-61, 2015.<\/li>\n<li>Nakako Izumi Nakajima#, <span class=\"bold uline\">Yoshihiko Hagiwara<\/span>#, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nPre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.<br \/>\n<span class=\"bold italic\">PLOS ONE,<\/span> 10(3):e0122582, 2015.<br \/>\n#Equal first author. *Corresponding author<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2014<\/h5>\n<ul class=\"treatise\">\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Penny Jeggo.<br \/>\nDNA double-strand break repair in a cellular context.<br \/>\n<span class=\"bold italic\">Clinical Oncology<\/span>(R Coll Radiol), 26(5):243-9, 2014.<\/li>\n<li>Napapat Amornwichet, Takahiro Oike , <span class=\"bold uline\">Atsushi Shibata<\/span>, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, <span class=\"uline\">Mayu Isono<\/span>, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno, Takashi Nakano.<br \/>\nCarbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe.<br \/>\n<span class=\"bold italic\">PLOS ONE<\/span>, 9(12):e115121, 2014.<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Davide Moiani, Andrew S. Arvai, Jefferson Perry, Shane M. Harding, Marie-Michelle Genois, Ranjan Maity, Sari van Rossum-Fikkert, Aryandi Kertokalio, Filippo Romoli, Amani Ismail, Ermal Ismalaj, Elena Petricci, Matthew J. Neale, Robert G. Bristow, Jean-Yves Masson, Claire Wyman, Penny A. Jeggo, John A. Tainer.<br \/>\nDNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.<br \/>\n<span class=\"bold italic\">Molecular Cell,<\/span> 53 (1), 7-18, 2014.\uff08citation 325: 2020\uff09<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2013<\/h5>\n<ul class=\"treatise\">\n<li>Nakako Izumi Nakajima, Holly Brunton, Ritsuko Watanabe, Amruta Shrikhande, Ryoichi Hirayama, \u3000Naruhiro Matsufuji, Akira Fujimori, Takeshi Murakami, Ryuichi Okayasu, Penny Jeggo and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nVisualisation of gH2AX foci caused by heavy ion particle traversal; Distinction between core track versus non-track damage.<br \/>\n<span class=\"bold italic\">PLOS ONE,<\/span> 14;8(8):e70107, 2013.<br \/>\n*corresponding author<\/li>\n<li>Andreas Kakarougkas, Amani Ismail, Yoko Katsuki, Raimundo Freire,<span>\u00a0<\/span><strong><span>Atsushi Shibata<\/span><\/strong><span>\u00a0<\/span>and Penny Jeggo.<br \/>\nCo-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.<br \/>\n<strong>Nucleic Acids Research,<\/strong><span>\u00a0<\/span>41(22):10298-311, 2013.<\/li>\n<li>Andreas Kakarougkas, Amani Ismail, Yoko Katsuki, Raimundo Freire, <span class=\"bold uline\">Atsushi Shibata<\/span> and Penny Jeggo.<br \/>\nOpposing roles for 53BP1 during homologous recombination.<br \/>\n<span class=\"bold italic\">Nucleic Acids Research,<\/span> 41(21), 9719-9731, 2013.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2011<\/h5>\n<ul class=\"treatise\">\n<li>Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, R. Scott Hansen, Penny A. Jeggo and <span class=\"bold uline\">Atsushi Shibata<\/span>*.<br \/>\nAnalysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2\/M checkpoint arrest.<br \/>\n<span class=\"bold italic\">Molecular and Cellular Biology,<\/span> 31(19):4022-4035, 2011.<br \/>\n*corresponding author<\/li>\n<li>Lisa Woodbine, Holly Brunton, Aaron A. Goodarzi, <span class=\"bold uline\">Atsushi Shibata<\/span>, and Penny A. Jeggo.<br \/>\nEndogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.<br \/>\n<span class=\"bold italic\">Nucleic Acids Research,<\/span> 39(16):6986-6997, 2011.<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Sandro Conrad, Julie Birraux, Verena Geuting, Olivia Barton, Amani Ismail, Andreas Kakarougkas, Katheryn Meek, Gisela Taucher-Scholz, Markus L\u00f6brich and Penny A Jeggo.<br \/>\nFactors determining DNA double-strand break repair pathway choice in G2 phase.<br \/>\n<span class=\"bold italic\">EMBO J,<\/span> 30(6):1079-92, 2011.\uff08citation 399: 2020\uff09<\/li>\n<li>Claire M. Connell*, <span class=\"bold uline\">Atsushi Shibata<\/span>*, Laura A. Tookman, Kyra Archibald, Magdalena B. Flak, Katrina J. Pirlo, Michelle Lockley, Sally P. Wheatley, Iain A. McNeish.<br \/>\nGenomic DNA damage and ATR-Chk1 signalling determine oncolytic adenoviral efficacy in human ovarian cancer.<br \/>\n<span class=\"bold italic\">Journal of Clinical Investigation,<\/span> 121(4):1283-97, 2011.<br \/>\n*These authors contributed equally to this work.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2010<\/h5>\n<ul class=\"treatise\">\n<li>Dana A. L\u00f6ser*,<span class=\"bold uline\">Atsushi Shibata<\/span>*, Akiko K. Shibata, Lisa J. Woodbine, Penny A. Jeggo and Anthony J. Chalmer.<br \/>\nSensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.<br \/>\n<span class=\"bold italic\">Molecular Cancer Therapeutics,<\/span> 9 (6),1775-87, 2010.<br \/>\n*These authors contributed equally to this work.\uff08citation 120: 2020\uff09<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Olivia Barton, Angela T. Noon, Kirsten Dahm, Dorothee Deckbar,Aaron A. Goodarzi, Markus L\u00f6brich, and Penny A. Jeggo.<br \/>\nRole of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G2\/M checkpoint arrest.<br \/>\n<span class=\"bold italic\">Molecular and Cellular Biology,<\/span> 30 (13), 3371\u20133383, 2010.\uff08citation 121: 2020\uff09<\/li>\n<li>Angela T. Noon, <span class=\"bold uline\">Atsushi Shibata<\/span>, Nicole Rief, Markus L\u00f6brich, Grant S. Stewart, Penny A. Jeggo and Aaron A. Goodarzi.<br \/>\n53BP1-dependent robust localized KAP\u20111 phosphorylation is essential for heterochromatic DNA double-strand break repair.<br \/>\n<span class=\"bold italic\">Nature Cell Biology,<\/span> 12 (2), 177-184, 2010.\uff08citation 315: 2020\uff09<\/li>\n<li>Markus L\u00f6brich, <span class=\"bold uline\">Atsushi Shibata<\/span>, Andrea Beucher, Anna Fisher, Michael Ensminger, Aaron A. Goodarzi, Olivia Barton and Penny A. Jeggo.<br \/>\ngH2AX foci analysis for monitoring DNA double-strand break repair \u2013 Strengths, limitations and optimization.<br \/>\n<span class=\"bold italic\">Cell Cycle,<\/span> 9 (4), 662-669, 2010.\uff08citation 566: 2020\uff09<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2009<\/h5>\n<ul class=\"treatise\">\n<li>Andrea Beucher, Julie Birraux, Leopoldine Tchouandong, Olivia Barton, <span class=\"bold uline\">Atsushi Shibata<\/span>, Sandro Conrad, Aaron A Goodarzi, Andrea Krempler, Penny A Jeggo, and Markus L\u00f6brich.<br \/>\nATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.<br \/>\n<span class=\"bold italic\">EMBO J,<\/span> 28, 3413-3427, 2009.\uff08citation 445: 2020\uff09<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Olivia Barton, Angela T. Noon, Dorothee Deckbar, Aaron A. Goodarzi, Markus L\u00f6brich and Penny A. Jeggo.<br \/>\nThe maintenance of ATM dependent G2\/M checkpoint arrest following exposure to ionizing radiation.<br \/>\n<span class=\"bold italic\">Acta Med. Nagasaki,<\/span> Vol. 53, 19-21, 2009<\/li>\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Daisuke Maeda, Hideki Ogino, Masahiro Tsustsumi, Takehiko Nohmi, Hitoshi Nakagama, Takashi Sugimura, Hirobumi Teraoka and Mitsuko Masutani.<br \/>\nRole of Parp-1 in suppressing spontaneous deletion mutation at non-repeat or short repeat of mononucleotide sequences in the mouse liver in the process of aging.<br \/>\n<span class=\"bold italic\">Mutation Research \u2013Fundamental and Molecular Mechanisms of Mutagenesis,<\/span> Vol. 664, 20-27, 2009.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2006<\/h5>\n<ul class=\"treatise\">\n<li>Ryo Sakasai, Keitaro Shinohe, Yosuke Ichijima, Naoyuki Okita, <span class=\"bold uline\">Atsushi Shibata<\/span>, Kinji Asahina and Hirobumi Teraoka.<br \/>\nDifferential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.<br \/>\n<span class=\"bold italic\">Genes to Cells,<\/span> Vol. 11, 237-246, 2006.<\/li>\n<li>Hideki Ogino, <span class=\"bold uline\">Atsushi Shibata<\/span>, Akemi Gunji, Hiroshi Suzuki, Hitoshi Nakagama, Takashi Sugimura, Mitsuko Masutani.<br \/>\nAgent-dependent effects of Parp-1 deficiency on DNA damage responses and genomic stability in mouse ES cells. In: Grier EV (ed), New Developments in Stem Cell Research, Hauppauge, New York, USA.<br \/>\n<span class=\"bold italic\">Nova Science Publishers, Inc,<\/span> pp 133-147, 2006.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2005<\/h5>\n<ul class=\"treatise\">\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani.<br \/>\nParp-1 deficiency causes an increase of deletion mutations and insertions\/rearrangements in vivo after treatment with an alkylating agent.<br \/>\n<span class=\"bold italic\">Oncogene,<\/span> 24, 1328-1337, 2005.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2004<\/h5>\n<ul class=\"treatise\">\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Mitsuko Masutani, Nobuo Kamada, Ken-ichi Masumura, Hitoshi Nakagama, Shizuko Kobayashi, Hirobumi Teraoka, Hiroshi Suzuki and Takehiko Nohmi.<br \/>\nEfficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes.<br \/>\n<span class=\"bold italic\">Environmental and Molecular Mutagenesis,<\/span> 43, 204-207, 2004.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2003<\/h5>\n<ul class=\"treatise\">\n<li><span class=\"bold uline\">Atsushi Shibata<\/span>, Mitsuko Masutani, Tadashige Nozaki, Nobuo Kamada, Hisako Fujihara, Ken-ichi Masumura, Hitoshi Nakagama, Takashi Sugimura, Shizuko Kobayashi, Hiroshi Suzuki and Takehiko Nohmi.<br \/>\nImprovement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation.<br \/>\n<span class=\"bold italic\">Environmental and Molecular Mutagenesis,<\/span> 41, 370-372, 2003.<\/li>\n<\/ul>\n<\/section>\n<section>\n<h5>2002<\/h5>\n<ul class=\"treatise\">\n<li>Mitsuko Masutani, Takushi Shimokawa, Masayuki Igarashi, Masa Hamada, <span class=\"bold uline\">Atsushi Shibata<\/span>, Sachiho Oami, Tadashige Nozaki, Hitoshi Nakagama, Takashi Sugimura, Tomio Takeuchi, Makoto Hori.<br \/>\nInhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues.<br \/>\n<span class=\"bold italic\">Proceedings of the Japan Academy,<\/span> Vol. 78, Ser. B, No. 1, 2002.<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<section>\n<h4>Grant<\/h4>\n<ol class=\"treatise\">\n<li>2017.4\uff5e2021.3 Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists A<\/li>\n<li>2014.4\uff5e2017.3 Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists A<\/li>\n<li>2014.4\uff5e2016.3 Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research<\/li>\n<li>2013.4\uff5e2014.3 Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up<\/li>\n<li>Gunma Foundation for Medicine and Health Science 300,000 JPY<\/li>\n<li>Kobayashi Foundation for Cancer Research 1,000,000 JPY<\/li>\n<li>Suntory Foundation 3,000,000 JPY<\/li>\n<li>The Sumitomo Foundation 1,300,000 JPY<\/li>\n<li>Takeda Science Foundation 5,000,000 JPY<\/li>\n<li>THE MITSUBISHI foundation<\/li>\n<li>The Uehara Memorial Foundation 5,000,000 JPY<\/li>\n<li>The Yasuda Memorial Foundation 2,000,000 JPY<\/li>\n<li>Daiichi Sankyo Foundation of Life Science 2,000,000 JPY<\/li>\n<li>Takeda Science Foundation 2,000,000 JPY<\/li>\n<li>The Cell Research Science Foundation 3,000,000 JPY<\/li>\n<li>Kowa Life Science Foundation 1,000,000 JPY<\/li>\n<li>The Sumitomo Foundation 1,500,000 JPY<\/li>\n<li>Takeda Science Foundation 3,000,000 JPY<\/li>\n<li>Mochida Memorial Foundation for Medical and Pharmaceutical Research 3,000,000 JPY<\/li>\n<li>The Uehara Memorial Foundation 2,000,000 JPY<\/li>\n<li>Terumo Life Science Foundation 1,000,000 JPY<\/li>\n<li>Astellas Foundation for Research on Metabolic Disorders 2,000,000 JPY<\/li>\n<li>Suzuken Memorial Foundation 1,000,000 JPY<\/li>\n<li>Takeda Science Foundation 2,000,000 JPY<\/li>\n<li>The Great Britain Sasagawa Small Grant 2012-2013: \u00a33000<\/li>\n<li>Daiwa Foundation Small Grants 2008: \u00a31500<\/li>\n<\/ol>\n<\/section>\n<section>\n<h4>International Conference<\/h4>\n<ul class=\"treatise\">\n<li><span class=\"blue\">Oral presentation<\/span> (Click <a href=\"https:\/\/shibataxlab.com\/english\/wp-content\/uploads\/2021\/02\/20abb0f760e302b06d348f183b153caf.pdf\" rel=\"noopener\" target=\"_blank\">here<\/a>)<\/li>\n<li><span class=\"blue\">Poster<\/span> (Click <a href=\"http:\/\/shibatalab.com\/english\/wp-content\/themes\/standard_black_cmspro\/img\/74400bed3287fb9cf23ea53e680f78a6.pdf\" rel=\"noopener\" target=\"_blank\">here<\/a>)<\/li>\n<\/ul>\n<\/section>\n<section>\n<h4>Japanese conference<\/h4>\n<p>Click <a href=\"http:\/\/shibatalab.com\/english\/wp-content\/themes\/standard_black_cmspro\/img\/5bdf93bf732d398b357af902fa95654d.pdf\" rel=\"noopener\" target=\"_blank\">here<\/a><\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>DSB repair pathway choice Transcription associated DSB repair in G1 Yasuhara et al., Cell Rep, 2022 HR initiat [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":31,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-683","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/pages\/683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=683"}],"version-history":[{"count":49,"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/pages\/683\/revisions"}],"predecessor-version":[{"id":1255,"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=\/wp\/v2\/pages\/683\/revisions\/1255"}],"wp:attachment":[{"href":"https:\/\/shibataxlab.com\/english\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}